Penn developed AI tools and datasets help tailor treatments for kidney patients
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Updates every hour. Last Updated: 13-Jan-2026 21:11 ET (14-Jan-2026 02:11 GMT/UTC)
Social and environmental factors may influence fitness ahead of surgery reveals research led by Lancaster University.
The study was led by PhD researcher Dr Donna Shrestha from Lancaster Medical School, where her research focuses on health inequalities in the surgical patient pathway. She is also a senior resident doctor with a specialist interest in colorectal surgery.
The research published in PLOS ONE suggests that patients from more socioeconomically deprived areas may have lower cardiorespiratory fitness at the time of preoperative assessment.
According to a study by Karolinska Institutet, nearly three times as many people under the age of 50 in Sweden are diagnosed with colorectal cancer today compared with the early 1990s. The study also shows that mortality is elevated in both younger and older patients for up to ten years after diagnosis.
Scientists discovered that three TCF7-expressing tumor-reactive T cell subpopulations exhibit selective expansion during ovarian tumor-infiltrating T cell production ex vivo. CD8+ TCF7+ Tpex cells demonstrate self-renewal capacity and generate stem-like progenies. CD8+ TCF7+ Tpex and CD4+ TCF7+ Tfh cells are both marked by the co-expression of CCR7 and CD200. Selectively expanding CCR7+CD200+ T cells enriches stem-like, tumor-reactive T cells, enabling precise ex vivo expansion of therapeutic T cell subpopulations for adoptive cell therapy.