Current regulations for nanomedicines overlook the effects of the different forms of the same element, such as ions, nanoparticles, and aggregates. In a recent study, Japanese researchers developed a new analytical method combining an asymmetric flow field-flow fractionation system and mass spectrometry to separately quantify these forms. This technique allows for better quality control and safety evaluation of metal-based nanomedicines, promoting their development and clinical use, with applications also extending to food, cosmetics, and the environment.

Gliomas are among the deadliest brain tumors, with limited treatment options and poor survival rates. Scientists from China identified FAM111B, a DNA-repair-associated protein, as a key driver of glioma progression. The study shows that FAM111B overexpression enhances tumor growth and aggressiveness by activating the PI3K/AKT pathway. This is the first research to link FAM111B to gliomas, offering a promising new biomarker and therapeutic target for this intractable disease.

Created to distinguish the most remarkable scientific discoveries in the biomedical field, this international award has a growing reputation as a prelude to the Nobel Prize since it distinguished two authors in a former edition, who were subsequently honoured with the Nobel Prize in Medicine.Created to distinguish the most remarkable scientific discoveries in the biomedical field, this international award has a growing reputation as a prelude to the Nobel Prize since it distinguished two authors in a former edition, who were subsequently honoured with the Nobel Prize in Medicine.

A research team from the GCAT|Genomes for Life project, one of the strategic initiatives of the Germans Trias i Pujol Research Institute (IGTP), has published a study in the journal Scientific Reports proposing a method to correct selection biases in population-based cohorts. The study represents a significant step forward in improving the reliability of data derived from such studies for public health research and precision medicine.

CNIC researchers have discovered that the heart forms from two independent cell types working in synchrony from gastrulation, offering new insights into congenital heart defects and potential regenerative therapies.

Research outcomes may provide insights to improve quality of life for patients and establish Singapore as a leader in medical innovation and patient care for this largely under recognised and understudied condition. 

The process of necrosis, a form of cell death, may represent one of the most promising ways to change the course of human aging, disease and even space travel, according to a new study from researchers at UCL, drug discovery company LinkGevity and the European Space Agency (ESA).