In the fight against cancer, immunotherapy – which aims to boost the body’s natural defences against cancer - is experiencing remarkable growth. Most of these treatments are based on CD8 T lymphocytes, ‘‘killer cells’’ able to eliminate diseased cells. A team from the University of Geneva (UNIGE) has explored an alternative approach involving CD4 T lymphocytes. Long considered mere auxiliary cells, their therapeutic potential has been considered of secondary importance. But the scientists have discovered that they also have strong killing capacity, while continuing to support other immune cells. Using cell engineering technologies, the team reprogrammed the cells to target a tumour marker found in many cancers, both in adults and children. These results, published in the journal Science Advances, offer hope for a faster therapeutic strategy that could benefit a greater number of patients.

Extrinsic fiber acoustic sensors have attracted considerable interest due to their exceptional sensitivity and extremely low minimum detectable pressure (MDP). However, this high sensitivity also introduces excessive phase drift, resulting in significant 1/f noise and complicating the demodulation process. In this study, we present a stabilized triple-phase demodulation (STPD) method that effectively suppresses 1/f noise and maintains a stable, drift-free phase output, achieving a low and flat noise floor of 173 μrad/Hz without the need for prior calibration. To further enhance performance, we design a labyrinth-inspired multiresonant membrane that enables broadband acoustic detection. As a result, the proposed sensor achieves a wideband response from 20 Hz to 15 kHz, a maximum phase sensitivity of 1.02 rad/Pa (−119.83 dB ref: 1 rad/μPa), and an MDP as low as 81.84 μPa/Hz at its first-order resonance. The system also demonstrates an impressive linear dynamic range of 115.72 dB, enabling reliable sound detection across a broad range of pressures.Extrinsic fiber acoustic sensors have attracted considerable interest due to their exceptional sensitivity and extremely low minimum detectable pressure (MDP). However, this high sensitivity also introduces excessive phase drift, resulting in significant 1/f noise and complicating the demodulation process. In this study, we present a stabilized triple-phase demodulation (STPD) method that effectively suppresses 1/f noise and maintains a stable, drift-free phase output, achieving a low and flat noise floor of 173 μrad/Hz without the need for prior calibration. To further enhance performance, we design a labyrinth-inspired multiresonant membrane that enables broadband acoustic detection. As a result, the proposed sensor achieves a wideband response from 20 Hz to 15 kHz, a maximum phase sensitivity of 1.02 rad/Pa (−119.83 dB ref: 1 rad/μPa), and an MDP as low as 81.84 μPa/Hz at its first-order resonance. The system also demonstrates an impressive linear dynamic range of 115.72 dB, enabling reliable sound detection across a broad range of pressures.