Researchers have developed an easy-to-apply antibacterial hydrogel by incorporating a biodegradable oligomer into a thermosensitive matrix. This hydrogel kills drug-resistant bacteria through a triple-action mechanism and demonstrates effective wound protection in biological models.

Rapid development of artificial intelligence requires the implementation of hardware systems with bioinspired parallel information processing and presentation and energy efficiency. Electrolyte-gated organic transistors (EGOTs) offer significant advantages as neuromorphic devices due to their ultra-low operation voltages, minimal hardwired connectivity, and similar operation environment as electrophysiology. Meanwhile, ionic–electronic coupling and the relatively low elastic moduli of organic channel materials make EGOTs suitable for interfacing with biology. This review presents an overview of the device architectures based on organic electrochemical transistors and organic field-effect transistors. Furthermore, we review the requirements of low energy consumption and tunable synaptic plasticity of EGOTs in emulating biological synapses and how they are affected by the organic materials, electrolyte, architecture, and operation mechanism. In addition, we summarize the basic operation principle of biological sensory systems and the recent progress of EGOTs as a building block in artificial systems. Finally, the current challenges and future development of the organic neuromorphic devices are discussed.

As Alzheimer’s disease (AD) becomes more prevalent, scientists are exploring new methods for its early detection. In a recent review, researchers from India outline how neuron-derived extracellular vesicles—tiny membrane-bound particles released by neurons—are emerging as a promising diagnostic tool for AD. The contents of these vesicles carry molecular clues on the health of neurons, and it may soon be possible to use them to predict the onset of AD several years in advance.

Research groups of Professors Weiqi Zhang, Haiyan Xu and Lin Wang from the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, reported a positively-charged dextran nano-photosensitizer (p-Dex PS) facilitates tumor-associated macrophage (TAM)-mediated delivery and sublethal light-induced metabolic reprogramming, which boosts the TAM polarization and subsequently the anticancer immune effects.