The International Society for Stem Cell Research (ISSCR), the largest professional organization of stem cell researchers from around the world, is concerned about a recent statement attributed to NIH that the agency will not renew research grants involving human fetal tissue (HFT), and that research with HFT is not conducted responsibly or transparently. In fact, research with HFT has been indispensable in advancing biomedicine and saving millions of lives, and it continues to play an essential role in accelerating research that benefits patients.

Research calculates £1.6 trillion ($2 trillion) learning debt from closures while masks and testing proved highly efficient in pre-vaccine period.

According to a new study, most climate models exploring wildfires’ impacts on air quality overlook the effect of heat from a fire in one location on altering weather patterns – and in turn air quality – in locations farther afield. The authors of this study report that wildfires in the western United States are worsening air quality in the West but, paradoxically, may be improving it in the East. Over recent decades, wildfires in the western United States have become more frequent and intense, releasing vast amounts of smoke, which can greatly degrade air quality both locally and in regions far downwind. Often assumed to worsen when wildfire smoke drifts eastward from the West, fine particulate pollution (PM2.5) from wildfires has long been a major health concern in the eastern United States, potentially contributing to thousands of premature deaths each year. While this conventional wisdom has long informed air quality and fire management policies nationwide, the intense heat released by fires, which is capable of altering air temperatures, destabilizing the atmosphere, and driving strong convection, isn’t fully understood. Because wildfire heat can alter large-scale atmospheric circulation, its role in shaping distant air quality has been underappreciated. Most climate models consider only smoke emissions and not fire heat, which may explain why they tend to overestimate wildfire-driven pollution in the East.

 

Using both observational data and climate model simulations that incorporate daily heat measurements, Qihan Ma and colleagues found that, during extreme wildfires in the West, PM2.5 actually declines in the East, not only during extreme events but also throughout the fire season. This occurs because the intense heat released by large fires drives strong convection, which changes weather patterns, suppresses eastward smoke transport, and promotes rainfall that helps cleanse the air. However, while fire heat can improve air quality in the East, wildfires still worsen pollution in the West. According to Ma et al., ignoring fire heat in current climate models leads to inflated nationwide health and economic impact estimates – by about 1,200 premature deaths and $3.3 billion in damages – highlighting the need for policies that recognize its role in shaping regional air quality and environmental equity. “The differential impacts of wildfires necessitate the more appropriate allocation of resources and policy intensity for fire management and regional pollution control,” write the authors. “With greening in a warming world, the accumulation of fuels will lead to increased fire heat release when wildfires occur. It is imperative to consider fire heat in the Earth system when conducting comprehensive climate simulations and wildfire risk assessments.” In a related Perspective, Yun Qian discusses the study and the implications of its findings in greater detail.

In a Policy Forum, Natalie Ram and colleagues discuss the concerning gaps in robust regulatory protection on direct-to-consumer genetic data and biospecimens. After declaring bankruptcy in March 2025, the direct-to-consumer (DTC) genetic testing company, 23andMe, sold the genetic data of over 15 million people worldwide to a nonprofit founded by 23andMe’s own CEO. Although the nature of the sale meant the data remained under familiar leadership, it was controversial and highlighted critical gaps in legal protection for genetic information. Inevitable future commercial sales of such data – potentially with no connection to the original company and its policies – raise the risk of privacy violations. According to Ram et al., companies can revise privacy policies, undermine consumer consent, or share sensitive genetic information with insurers, researchers, or law enforcement, leaving consumers vulnerable. The authors argue that, without stronger safeguards, biospecimens and data may be subject to exploitation, commercialization, or misuse, raising risks that extend to global security. Unlike the European Union, the U.S. lacks a comprehensive federal privacy framework when it comes to safeguards for genetic data. Although the U.S. Congress is exploring legislation, including the Genomic Data Protection Act and the Don’t Sell My DNA Act, Ram et al. highlight how these proposals fall short of offering meaningful protection for consumers. “The 23andMe bankruptcy reminds us how vulnerable people’s DTC genetic data are to sale and potential misuse, given gaps in the law and the predictable vagaries of commercial markets,” write the authors. “Congress and other lawmakers must act to robustly protect DTC genetic data and biospecimens into the future.”

To harness the full potential of new medical technologies, a new white paper calls for significant FDA reforms to streamline clinical trials, provide greater certainty for innovators and speed game-changing treatments to more patients.