Macronucleophagy helps control micronucleophagy to protect yeast cells during stress. Through extensive experiments with yeast mutants, researchers from Science Tokyo found that disrupting macronucleophagy triggers excessive micronucleophagy, causing cell death. They further identified that this hyperactivation is driven by the accumulation of Nuclear vacuolar junction (Nvj1), a key nuclear membrane protein. These findings shed light on the links between different autophagy pathways under challenging conditions, which are crucial to maintain cell health.

A new study, co-led by a University of Massachusetts Amherst researcher, set out to identify the most effective strategies for helping people quit vaping. The findings, published today in the Cochrane Database of Systematic Reviews, suggest that varenicline, a prescription medication often used to help people stop smoking, and text message-based interventions can help people quit.