Hypermobile Ehlers–Danlos syndrome (hEDS) is one of the most common heritable connective tissue disorders. Early estimates have reported that this genetic disorder affects at least one in 5,000 individuals and more recently it has been estimated to affect upwards of 1-3% of the population worldwide. Clinically, hEDS is characterized by generalized joint hypermobility, tissue fragility including capillary fragility associated with easy bruising, poor wound healing and atrophic scarring, and skin hyper-extensibility. A particularly concerning complication of hEDS that has been underrecognized is the occurrence of fragility fractures in infancy and childhood and the social and legal consequences that can result from diagnostic errors.

Despite the clinical recognition of hEDS for decades and advances in genetic sequencing technologies, the molecular basis of hEDS has remained largely mysterious until now. Using for the first time machine learning with rigorous subject-level statistical analysis, researchers from Boston University Chobanian & Avedisian School of Medicine believe that hEDS is not a single-gene disorder, but rather involves a combination of genetic variations affecting three key biological systems. They stress that these biological associations represent baseline genetic data that prioritize hypotheses for future in-depth investigation, rather than established disease mechanisms.

When Asian American Olympians Chloe Kim and Eileen Gu competed in their first Winter Games, they were treated differently by the U.S. media, a new University of Michigan study suggests.

Cash transfer programs, which provide money directly to recipients, are growing in the United States, but face significant scrutiny, with questions over their value. In addition, some contend that these payments can lead to harm—recipients, they claim, will use the cash to immediately buy alcohol or drugs, leading to injury or death. However, a new 11-year study of a long-standing cash-transfer program in Alaska finds no evidence that direct cash payments increase the risk of traumatic injury or death.