Researchers have developed a laser-assisted method that rapidly detects tiny amounts of CEACAM-5, a colorectal cancer biomarker, in blood. The technique enhances antibody–antigen interactions and achieves detection even at low concentrations within minutes. The researchers also identified nanoscale CEACAM-5 aggregates that may enhance the method’s sensitivity.

New research from the Garvan Institute of Medical Research has revealed for the first time that two closely related bowel diseases, currently treated in the same way, are fundamentally different. The findings help explain why one carries a much higher risk of colon cancer – and point to the need for different approaches to treatment.

Adoptive T cell therapy works well in some blood cancers but remain less effective against solid tumors. Researchers developed T-FOLactis, a probiotic–T cell chimera that links engineered bacteria directly to T cells. In colorectal cancer models, the platform improved tumor localization, strengthened local immune coordination, and produced greater antitumor activity than conventional T cell therapy.