Researchers compressed the Fe-N bond in uniform Fe₁-N₄single-atom catalysts from 2.03 to 1.93 Å without changing their coordination structure. This 0.1 Å change promoted electron accumulation at Fe centers, enhanced peroxide activation and increased C-H bond oxidation activity nearly 23-fold. The study establishes a direct relationship between bond distance, electronic structure and catalytic performance, extending precise catalyst design to the subangstrom scale.

Fungi represent a cornerstone of industrial biotechnology, serving as indispensable platforms for the production of enzymes, organic acids, and high-value pharmaceuticals. In the era of synthetic biology and green manufacturing, the engineering of fungal cell factories offers unparalleled opportunities to address global challenges in sustainability, human health, and the circular bioeconomy. This article collection aims to capture the cutting-edge advances in fungal biomanufacturing, ranging from foundational metabolic engineering to the development of robust industrial strains.

Filamentous fungi and yeasts are powerful platforms for sustainable chemical production. As industries shift away from petrochemical-based processes, engineered fungal cell factories offer a renewable route to high-value compounds—from therapeutic alkaloids to biodegradable polymers. By integrating cutting-edge tools like CRISPR-Cas9, biosensors, and dynamic pathway regulation, we can overcome long-standing bottlenecks in titer, rate, and yield. Furthermore, linking fungal biomanufacturing with medicinal plant biomass valorization directly supports the circular bioeconomy, reduces agricultural waste, and enables the sustainable production of bioactive natural products that are otherwise difficult to source.

This collection will serve as a platform for presenting innovative strategies that bridge the gap between laboratory-scale design and industrial-scale application, emphasizing the critical role of fungi in shaping a sustainable manufacturing future. We invite contributions that explore the full spectrum of fungal biotechnology, with a focus on leveraging the unique metabolic versatility of yeast and filamentous fungi. Topics of interest include the design and optimization of fungal cell factories for the sustainable production of biofuels, biopolymers, and high-value natural products. We particularly welcome studies that integrate systems biology, CRISPR-based genome editing, and process engineering to overcome current bottlenecks in titers, yields, and rate of products. Additionally, given the growing significance of traditional medicine and functional foods, this issue will highlight the role of fungal systems in the herb bioprocessing to produce bioactive compounds.

Topics of Interest in details:

Development and optimization of Saccharomyces, Yarrowia, and non-conventional yeasts for industrial applications.

Pathway construction, flux optimization, and dynamic regulation in fungal hosts.

Development of genetic parts, CRISPR-Cas9/12 tools, and biosensors for fungal systems.

Heterologous biosynthesis of terpenoids, flavonoids, alkaloids, polyketides, and fungal secondary metabolites.

Biotransformation, valorization, and sustainable production of bioactive compounds from medicinal plant biomass.

Morphology engineering and harnessing Aspergillus, Trichoderma, and Basidiomycetes for enzyme and chemical production.

Bioprocess design, scaling-up strategies, and techno-economic analysis for fungal-based manufacturing.

 keywords:

Yeast cell factories

Metabolic engineering

Synthetic biology

Natural products

Herb bioprocessing

Filamentous fungi

CRISPR-Cas9

Sustainable bioprocesses

Adoptive T cell therapy works well in some blood cancers but remain less effective against solid tumors. Researchers developed T-FOLactis, a probiotic–T cell chimera that links engineered bacteria directly to T cells. In colorectal cancer models, the platform improved tumor localization, strengthened local immune coordination, and produced greater antitumor activity than conventional T cell therapy.

Chemical reactions are often written as simple equations: starting materials go in, and a product comes out. In reality, the samesubstrates can follow many different pathways depending on their concentrations, temperature, catalysts, and other conditions.

Exploring all of these possibilities by hand is practically impossible. Now, advances in laboratory automation and chemical artificial intelligence are allowing researchers to systematically map this vast “reaction hyperspace”—and uncover chemistry that may have remained hidden even in reactions studied for more than a century.

To address this question, scientists led by Prof. Bartosz A. GRZYBOWSKI, Director of the Center for Algorithmic and Robotized Synthesis within the Institute for Basic Science (IBS) used an automated robotic platform to explore 960 different sets of conditions for the Biginelli reaction, a classic multicomponent reaction first reported in 1891.

Weather data could help predict up to three days in advance when the number of out-of-hospital cardiac arrests is likely to rise above average, according to a nationwide study of more than 114,000 cases by researchers from Semmelweis University, the Budapest University of Technology and Economics, and the Hungarian National Ambulance Service. The study, published in Public Health, found that lower temperatures emerged as one of the most important weather-related risk factors examined. In the future, models based on weather forecasts could help people with cardiovascular disease and their families prepare for higher-risk periods, while also supporting ambulance services and hospitals in managing expected increases in demand. 

A research team at the Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, has used scanning nitrogen-vacancy microscopy and vector magnetic field reconstruction to demonstrate at the nanoscale that zigzag graphene nanoribbons embedded in hexagonal boron nitride exhibit strong perpendicular magnetic anisotropy. The work was published in the Journal of Functional Materials and Devices.

Scientists use light-driven chemistry to synthesize a valuable pharmaceutical building block and generate trifluoromethyl radicals directly from inexpensive, low-toxicity fluoroform.