♦Successful development of a stealth cloak (invisibility cloak) to protect nanomachines introduced into living organisms from foreign body reactions over extended periods: Constructed a stable ion pair network composed of polyanions and polycations on the nanomachine surface, devising a structure that prevents protein adsorption and attacks from macrophages.

♦Achieved ultra-long circulation in vivo with a half-life exceeding 100 hours after intravenous administration (10 times longer than previous stealth DDS systems).

♦Nanomachines equipped with asparaginase, an enzyme that breaks down L-asparagine, circulate long-term within the body, depleting L-asparagine—essential for cancer cell survival—from tumor tissues.

♦Confirmed the efficacy of starvation therapy for refractory breast cancer using a mouse model.

♦Furthermore, it breaks down the thick stroma (fibrous tissue) that blocks drug penetration into pancreatic cancer (such as immune checkpoint inhibitors), achieving extremely high efficacy (long-term survival) through synergistic effects with cancer immunotherapy.

♦A paper detailing the presentation content：

Junjie Li^*, Kazuko Toh, Panyue Wen, Xueying Liu, Anjaneyulu Dirisala, Haochen Guo, Joachim F. R. Van Guyse, Saed Abbasi, Yasutaka Anraku, Yuki Mochida, Hiroaki Kinoh, Horacio Cabral, Masaru Tanaka, and Kazunori Kataoka^*

Nature Biomedical Engineering (2025)

https://doi.org/10.1038/s41551-025-01534-1

Researchers from Charles University and the Institute of Physics, Czech Republic, have demonstrated heat-based computation in a memory device made from the antiferromagnetic metal.  Inspired by how the human brain processes and stores information, the ultrafast heat-based short-term memory logic is combined with electrically readable magnetic long-term storage in a single device. The time scale of heat-based operations can be as short as sub‑nanoseconds, making these bio-inspired devices compatible with the GHz frequencies of standard electronics.

- Wafer-Scale Integration of Next-Generation Memristor Semiconductors: Establishing a World-Class Platform for High-Density, Low-Power Computing

- Research Findings Published in Nature Communications

Scientists from Harbin Institute of Technology, together with collaborators from The University of Hong Kong and Southern University of Science and Technology, has developed a decoupled titanium dioxide–viologen hybrid material that integrates energy storage and color-changing display functions within a single system. This breakthrough enables high-capacity, high-efficiency electrochromic energy storage and marks an important step toward the next generation of smart, interactive energy devices.

Parkinson’s and Alzheimer’s diseases are the two most common neurodegenerative disorders, affecting millions of people worldwide. Published in the Journal of Neuroscience, new research from the Okinawa Institute of Science and Technology (OIST) suggests a shared molecular cascade between the two diseases which causes synaptic dysfunctions, advancing our understanding of how their symptoms are produced. 

A collaborated research team led by Prof. MA Yanwei from the Institute of Electrical Engineering (IEE) of Chinese Academy of Sciences (CAS), has shattered records in the current-carrying performance of iron-based superconducting wires.