A newly developed bioinformatics tool, MPGK, integrates Mendelian randomization, polygenic risk score, Gene Ontology, and the Kyoto Encyclopedia of Genes and Genomes pathway analyses into a unified command-line workflow. Designed to reduce the learning curve for beginners, MPGK automates complex post-genome-wide association study analyses while maintaining reproducibility and flexibility. Validation using publicly available datasets demonstrated its ability to identify disease associations and biological pathways consistent with prior research.

Cells naturally exchange cytoplasmic components like proteins, RNA, and mitochondria, but scientists lack tools to control such transfers in living cells. Now, researchers in Japan have developed a nanotube membrane-based injector—a system that enables high-efficiency, minimally invasive cytoplasmic transfer between cells. This platform preserves cell viability and can even transfer functional mitochondria, opening new possibilities for cell engineering and regenerative medicine.

A team led by principal investigators Bobo Dang and Ting Zhou at Westlake University/Westlake Laboratory reported in Science a high-throughput platform for engineering fast-acting covalent protein therapeutics. Their work, titled “A high-throughput selection system for fast-acting covalent protein drugs,” opens new avenues for next-generation biologics.