Creatinine is a widely used marker of kidney function, but testing it still often depends on bulky instruments or methods prone to interference. 

The Robert A. Winn Excellence in Clinical Trials Award Program (Winn Awards) is pleased to announce that AstraZeneca has joined as a funding partner. AstraZeneca will support five medical students in the 2026 Winn Clinical Investigator Pathway Program (Winn CIPP), a six-week immersive summer program that prepares future physicians and clinical researchers to expand access to clinical trials and engage medically underrepresented communities. This partnership strengthens the Winn Awards’ mission of Better Science For All by providing opportunities for medical students from all backgrounds to explore community-engaged clinical research opportunities.

A new study led by Aalto University examines how AI companions impacted people’s mental health and social lives over a two-year period. Combining large‑scale data from the discussion platform Reddit with in-depth interviews, it showed that while interacting with an AI companion can support users, it also coincided with increased signs of distress in their online language. The work offers one of the first causal, long-term examinations of AI companions’ mental health impact at scale, grounded in first‑hand accounts of users’ everyday lives.

Existing plasmonic systems lack the required anisotropy for robust chiral control and tunable light confinement. Researchers demonstrate hyperbolic localized plasmon resonances in the anisotropic two-dimensional crystal MoOCl₂. Unlike conventional plasmons, these modes are intrinsically one-dimensional, independent of the metal–insulator–metal (Z-) gaps, and can generate strong optical chirality without breaking geometric symmetry. This approach could enable a versatile nanophotonic platform for polarization engineering, chiral sensing, and integrated quantum nanophotonic devices.

In a multicenter retrospective Chinese ICU cohort (5 hospitals, 2012–2023; 9,221 pediatric suspected-infection admissions; 13.4% mortality), the Phoenix Sepsis Score showed only moderate discrimination for in-hospital death (AUROC 0.60). Using XGBoost/SHAP-guided, clinically feasible predictors, the authors created PSS+, presented as a logistic regression nomogram, improving discrimination in internal (AUROC 0.75) and external (AUROC 0.71) validation versus PSS-4/8 and pSOFA.

Nanofilm electrodes capable of detecting stress in plants through bioelectric potentials could pave the way for more resilient agriculture, report researchers from Institute of Science Tokyo. Thanks to the electrode’s small thickness, leaf surface hairs can easily pierce through it, enabling stable and long-term electrical contact without compromising the leaf’s natural processes. This work could help improve crop yields by enabling early detection of stress in plants.

A multi-channel wearable scent display developed at Institute of Science Tokyo allows a user to experience multiple scents while exploring virtual environments. Based on virtual scenes, the device can blend up to eight fragrances in real time and deliver them with precise control of odor intensity. By synchronizing smell with virtual reality content, the device enables better immersion and realism—opening new possibilities for enhanced digital entertainment, realistic simulation training, and future digital scent technologies.

Artificial intelligence (AI) is increasingly being explored as a tool to support clinical decision-making, yet its real-world performance in pediatric diagnosis remains unclear. Now, a Pediatric Investigation study using authentic clinical cases reports that advanced AI models outperform clinicians in diagnostic accuracy, particularly for rare diseases, while a combined human-AI approach achieves the highest overall success. The findings highlight the potential of AI as a complementary tool to improve diagnostic precision and patient outcomes.