A new study of over 3,000 Japanese firms reveals that companies often set overly ambitious earnings targets after previously missing their goals—an effort to restore investor confidence. This strategic move, known as “organizational impression management,” helps firms manage market perceptions despite the risk of repeated failure. The research also finds that institutional investors, analysts, and board diversity can temper this behavior, offering fresh insight into corporate communication and investor relations.

In a paper published in National Science Review, the team of Pro. Liu present an innovative computational framework, the sample-perturbed Gaussian graphical model (sPGGM), designed to analyse disease progression and identify pre-disease stages at the specific sample/cell level based on optimal transport theory and Gaussian graphical models. The proposed sPGGM provides a new single-sample way to identify the pre-disease state and discover signaling molecules leading to potential disease, which showcases exceptional effectiveness and robustness for both bulk and single-cell data analyses, offering a novel perspective for personalized disease prediction.

Brain aneurysm is the leading cause of brain hemorrhages. To combat the growing cases of brain aneurysms in China, researchers are conducting a large-scale, national clinical study to evaluate the best surgical and endovascular treatments for unruptured brain aneurysms. The China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA) has enrolled up to 25,000 patients across 83 hospitals and is all set to refine the treatment guidelines for brain aneurysms in Chinese patients.

Northwestern Medicine scientists have developed an AI tool called iSeg that not only matches doctors in accurately outlining lung tumors on CT scans but can also identify areas that some doctors may miss, reports a large new study.

A fast, precise new 3D printing advance samlessly merges soft and hard properties into a single object using different colors of light. The breakthrough technology could pave the way for next-generation prosthetics, flexible medical devices and stretchable electronics that move naturally with the body, much like a human joint or ligament.