Progesterone insensitive has long hindered fertility-preserving treatment for endometrial cancer. Now in Science Bulletin, researchers from Peking University People's Hospital and Peking University, in collaboration with Beihang University show that cholesteryl ester accumulation in the tumor microenvironment predicts response. Adding statins to standard therapy reverses progesterone insensitivity, significantly increasing the likelihood of both achieving endometrial cancer remission and preserving future fertility.

The process of embryo implantation is complex yet highly coordinated, involving differentiation of multiple cell types and dynamic mechanistic or compensatory shifts in metabolic patterns. Metabolic regulation plays a critical role in embryo implantation by modulating embryo competence and endometrial receptivity. Accordingly, metabolites function not only as sources of energy but also as signaling molecules that orchestrate communication between the endometrium and blastocyst. Here, we review the regulatory roles of key metabolites, including carbohydrates, lipids, amino acids, and their derivatives in various reproductive processes, such as blastocyst formation and activation, establishment of uterine receptivity, and embryo implantation. Interpretation of metabolic signaling may help to elucidate the intricate process of embryo implantation and provide new insights into potential clinical interventions and improvements in assisted reproductive technology.

A research team led by City University of Hong Kong (CityUHK), in collaboration with the University of Zurich, has uncovered the first comprehensive map of how the anti‑ageing protein Klotho operates in distinct regions of the kidney, resolving long‑standing scientific uncertainties about its physiological roles.

RMIT has launched its Food Innovation Hub at the University’s Bundoora campus, strengthening future food research, education and workforce development in Melbourne’s north and across Australia.

Researchers at Huazhong University of Science and Technology have developed an IRS-assisted UAV FSO system that unifies intermittent jamming, composite channel effects, and performance–cost optimization, slashing outage probability tenfold within budget for military, disaster response, and 6G applications.