This comprehensive review explores the scientific potential of polyherbal formulations as advanced, multi-targeted solutions for anti-aging skincare. It delves into the intricate mechanisms of skin aging, driven by both intrinsic factors like oxidative stress and extrinsic factors such as UV radiation, which lead to collagen degradation and inflammation. The article highlights seven key medicinal plants—including Curcuma longa, Glycyrrhiza glabra, and Withania somnifera—and their potent phytoconstituents like curcumin and withanolides. These compounds work synergistically to combat aging by enhancing skin hydration, boosting collagen synthesis, inhibiting destructive enzymes (MMPs), and modulating oxidative stress. A significant focus is placed on modern delivery systems—such as liposomes, ethosomes, and emulgels—which are crucial for enhancing the stability, skin penetration, and bioavailability of these herbal actives. By bridging traditional ethnobotanical knowledge with contemporary cosmeceutical science and technology, the review positions polyherbal formulations as sustainable, effective, and therapeutically viable alternatives to conventional synthetic anti-aging products, offering a holistic approach to skin rejuvenation.

New Joint Lab marks ŌURA’s first research entity in the APAC region, deepening a six-year partnership with NUS focussing on key health behaviours including sleep and physical activity