Improved electrical conduction in the lesioned heart
Peer-Reviewed Publication
Updates every hour. Last Updated: 18-Dec-2025 04:11 ET (18-Dec-2025 09:11 GMT/UTC)
During a heart attack, heart muscle cells die and are replaced by scar tissue. This delays the electrical conduction in the heart and favours the onset of cardiac arrhythmia. To reduce this potentially life-threatening complication, researchers at the University Hospital Bonn (UKB) and the University of Bonn intended to partially restore electrical conduction in the scar tissue. To this end, they developed a gene therapy in mice to enrich the gap junction protein connexin 43 in the scar area in order to improve electrical conduction. By this approach, the research team could significantly reduce the frequency of arrhythmia in lesioned hearts. The results are recently published in the Journal of Physiology.
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