Genos: A large human-centric genomic foundation model transforming medi-cine and health research
Peer-Reviewed Publication
Updates every hour. Last Updated: 6-Nov-2025 04:11 ET (6-Nov-2025 09:11 GMT/UTC)
Introducing Genos, an open genomic foundation model for high-quality human genomes across global populations, built to advance understanding of the genome and its diversity. Genos achieves single-nucleotide precision over a context of 1 million bases and uses a Mixture of Experts (MoE) architecture that is practical to deploy and economical to run. We provide two variants, 10B and 1.2B, so teams can match compute and latency needs. Trained on 636 high-quality assemblies representing diverse ancestries, with ~1.6T training tokens for the 1.2B model and ~2.2T for the 10B model, Genos learns the genome itself and generalizes to population-scale analyses. With efficient routing and scalable inference, Genos connects sequence to function and powers tools for discovery and diagnostics, and a complementary 4B multimodal language model pairs genomic signals with text to enable omics-aware reasoning in those tools. Explore code, weights, and docs on GitHub, Hugging Face, ModelScope, and zero2x.
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