A newly identified role for C/EBPγ reveals how lung adenocarcinoma cells simultaneously acquire invasive properties and strengthen DNA repair. The findings uncover a potential driver of treatment resistance and a promising therapeutic target.

A research team led by Professors Weiwei Jin and Wei Huang from China Agricultural University, in collaboration with Tianjin Agricultural University and the University of São Paulo in Brazil, elucidated how two anther-specific plasma membrane hexose transporters, ZmSWEET6a and ZmSWEET6b, coordinately regulate pollen wall development and cellular homeostasis. The study has been published online in The Crop Journal.

International research teams led by China Agricultural University and the Chinese Academy of Agricultural Sciences have identified and cloned a new semi-dwarfing gene, Sdd1 (semi-dwarf and dense-spike 1), that modulates plant height and spike architecture through a distinct hormonal balancing mechanism—offering breeders a fresh genetic resource to fine-tune wheat architecture.

High-coverage Jomon and Yayoi genomes reveal continuity with modern Japanese, continental ancestry, and prehistoric starch adaptations in Japan.

Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan have discovered that the natural turnover of gut cells in the fruit fly depends on how much food the flies get, rather than any specific nutrient. They found that gut cell death was prevented when nutrient levels were high and the insides of gut cells were viscous and less fluid. Published in Proceedings of the National Academy of Sciences, this finding goes against traditional ideas in nutrient biology, which hold that nutrient sensing relies on biological signaling pathways activated by specific nutrients.

A team led by Penn State researchers has developed a synthetic mimic of an enzymes that drives an enzyme-like reaction, requiring only oxygen and producing only water as waste.

A growing body of evidence suggests that a rare epithelial cell type known as the tuft cell may play a far more significant role in cancer than previously recognized. A recent review proposes that tumors expressing the tuft cell master regulator POU2F3 represent a distinct molecular class of “tuft cell-like” cancers spanning multiple organs, including the lung, pancreas, stomach, colon, breast, prostate, and neuroendocrine tissues. These tumors exhibit unique biological characteristics that may create new opportunities for diagnosis, prognosis, and targeted therapy.

A growing understanding of RNA biology is reshaping how scientists view the relationship between environmental toxicants, brain development, and neurodegenerative disease. A new review highlights the emerging importance of N6-methyladenosine (m⁶A), the most common RNA modification in cells, as a key regulator of nervous system development and a potential contributor to neurological damage caused by toxic environmental exposures.

Researchers combined family genetic studies with AI molecular biology to find a new candidate drug to treat osteoarthritis. In cells in a dish, the new compound prevents OA-associated changes and promotes cell health.