Osteogenesis – Angiogenesis coupling via interlineage paracrine signaling
Peer-Reviewed Publication
Updates every hour. Last Updated: 21-Oct-2025 20:11 ET (22-Oct-2025 00:11 GMT/UTC)
The precise mechanism of cellular condensation and regeneration is not well-understood in organogenesis. For advances in regenerative medicine, understanding these mechanisms is crucial. In a new study, researchers used single-cell transcriptomics to understand the composition of human dental follicles and dental papillae. They found a PDGFRA+ mesenchymal stem cell with odontogenic potential that interacts with endothelial cells via paracrine signaling to stimulate angiogenesis, showing promise for future therapeutics in dental regenerative medicine.
The University of Bath, in collaboration with the University of Edinburgh, has completed the largest-ever study on growth and biological maturation in global football.
The research, commissioned by the Scottish FA, explores how relative age and biological maturity influence talent identification and development across the Club Academy Scotland (CAS) system.
Findings suggest a significant selection bias toward early maturing players, which may lead to missed opportunities for talented but later-developing athletes.
A new pilot rule has been introduced within the CAS system, enabling clubs to group players by biological rather than chronological age - offering greater support for late developers.
The next phase of research will examine the relationship between growth-related injuries and player development, with injury prevention interventions to follow.
Two researchers from the Leibniz Institute for Tropospheric Research (TROPOS) were honoured at the 21st International Electromagnetic and Light Scattering Conference in Milazzo, Italy:
Prof. Andreas Macke, Director of TROPOS was honoured with the "Elsevier van de Hulst Prize for Light Scattering" 2025 for his significant contributions to the understanding of scattering properties of atmospheric ice crystals. Prof Macke has developed and applied light scattering models based on geometrical optics for complex irregular ice crystals and thus achieved a breakthrough in the consideration of realistic crystal structures. His models and results are used worldwide in numerous scientific fields such as astrophysics, biology, medicine and, of course, atmospheric physics. The prize honours the life's work of an individual scientist who has made a pioneering contribution to the research field of electromagnetic scattering by particles and its applications.
Dr Moritz Haarig from TROPOS received the AS&T Young Scientist Award for the best presentation at the conference. The AS&T Award has been presented since 2025 for outstanding conference contributions by young scientists.
In the paper published on Science of Traditional Chinese Medicine(STCM), the authors utilized synthetic biology technology to create the first artificial herbal cell (AHC) based on a traditional Chinese medicine (TCM) formulation: Compound Danshen Yeast 1.0. This breakthrough provides foundational technology for producing TCM formulations through one-step fermentation using simple carbon sources like glucose and ethanol—eliminating the need for wild harvesting or cultivation of medicinal herbs. By harnessing synthetic biology, the team reprogrammed a single yeast strain to simultaneously synthesize three classes of active ingredients—notoginsenosides (protopanaxadiol), tanshinone diterpenoid (miltiradiene), and borneol.