In a paper published in Molecular Biomedicine, the authors underscore the heterogeneity of Cancer-associated fibroblasts (CAFs) by elaborating on their origins, types and function. Most importantly, by elucidating the direct or indirect crosstalk between CAFs and immune cells, the extracellular matrix, and cancer cells, they emphasize the tumorigenicity of CAFs in cancer. Finally, they highlight the challenges encountered in the exploration of CAFs and list targeted therapies for CAF, which have implications for clinical treatment.

A new study by Tel Aviv University and Ben-Gurion University of the Negev reveals groundbreaking findings about the famous Rujm el-Hiri site (known as the "Wheel of Ghosts") in the Golan Heights. Based on geomagnetic analysis and tectonic reconstruction, the researchers determined that geodynamic movement over 150 million years, at an average rate of 8–15 mm per year, caused significant shifts in the ground, rotating and reorienting it over millennia. This finding challenges the widely held theory that the structure was used as an astronomical observatory, as the original alignment of the walls and entrances does not correspond to celestial observations, as previously hypothesized.

The creation of more fox-free safe havens and greater collaboration between government and landowners is needed to ensure the survival of a species of wallaby, an expert from The Australian National University (ANU) argues. 

The Parma wallaby, also known as the white-throated wallaby, is listed as a vulnerable species in Australia, while the International Union for Conservation of Nature (IUCN) classifies it as Near Threatened. The marsupial is found along the Great Dividing Range in northern New South Wales. 

Researchers from Kyushu University, Japan, have developed a new method to simultaneously and non-invasively measure membrane voltage and calcium levels in the neurons of awake animals. This innovation revealed for the first time that changes in membrane voltage and intracellular calcium encode different information about a stimulus. These findings reveal fresh perspectives on how neurons process sensory information.

Researchers from Fudan University have developed an innovative glycopeptide enrichment strategy, offering a rapid and efficient tool for comprehensively profiling of glycosylation types, including N-glycosylation, O-GlcNAcylation, and O-GalNAcylation. This efficient method minimizes sample input and simplifies workflows, providing a powerful tool for studying glycosylation’s roles in biology and disease.

A research team from the Department of Mechanical Systems Engineering, Tokyo University of Agriculture and Technology has developed an explainable AI method to observe the splashing drops of different liquids while impacting a solid surface. This achievement provides important insights into the phenomenon of splash, which is important for various applications, such as aeronautics, biology, chemical and mechanical engineering, materials, acoustics, and combustion.

Can we examine the teeth of living fish and other vertebrates in detail, repeatedly over time, without harming them? 

Previously, small animals often had to be euthanized to obtain precise information, but now scientists have found a new way to humanely study detailed dental characteristics of vertebrates. This customizable method can be used for both living animals and museum specimens and has been published in the Journal of Morphology. 

Researchers at the Okinawa Institute of Science and Technology (OIST) and their collaborators applied human dental impression techniques to study fish teeth in a species called Polypterus senegalus. This fish has been separated from other fish species for about 360 million years. Due to this long period of evolutionary isolation, Polypterus still has many primitive characteristics that provide important information on the early development of bony fish.