Mononuclear macrophages serve as the primary target cells for the in vivo metabolism of iron-based nanomaterials. The uptake of nanoparticles by mononuclear macrophages is influenced by various factors, such as particle size, surface charge, and administration route, which subsequently affect the metabolic process. During this process, iron-based magnetic nanomaterials can induce macrophage reprogramming and participate in immune modulation. This is primarily reflected in their regulation of macrophage function through enzyme-like activities, intracellular iron metabolism, cell signaling pathways, mitochondrial energy metabolism, and responses to magnetic fields.

Three University of Texas at Arlington faculty members were recognized for their research and creative contributions as part of the faculty research honors. J. Ping Liu, professor of physics, received the University Award for Distinguished Record of Research or Creative Activity. Kyrah Brown, associate professor of kinesiology, and Ben Jones, associate professor of physics, received the University Award for Outstanding Research or Creative Accomplishment.

Chimpanzee naive pluripotent stem cells (PSCs) can now be grown in cellular cultures, reveals a recent study. They successfully created chimpanzee early embryo models, called ‘blastoids,’ and found that the inhibition of a specific regulatory gene is essential for chimpanzee PSC self-renewal. They also developed a feeder-free culture system, eliminating the need for mouse-derived feeder cells as support. These findings provide valuable insights into primate embryology and could advance stem cell research and regenerative medicine.

In a new study published in Science Bulletin, researchers from West China Hospital of Sichuan University present the largest human T cell reference for 68 subtypes and states, alongside STCAT, an automated annotation tool achieving 28% higher accuracy than existing methods. Their systematic analyses reveal T cell subtype dynamics in cancer and COVID-19, offering a valuable resource for the community. They also develop a TCellAtlas database for browse T cell expression profiles and analyzing customized scRNA-seq data by STCAT tool.