A decade ago, researchers introduced a new model for studying Alzheimer’s disease. Known as “Alzheimer’s in a dish,” the model uses cultures of mature brain cells suspended in a gel to recapitulate what takes place in the human brain over 10 to 13 years in just six weeks. But does the model truly produce the same changes that take place in patients? In a new study, researchers from Mass General Brigham, in collaboration with colleagues at Beth Israel Deaconess Medical Center (BIDMC), created an algorithm to assess, in an unbiased manner, how well models of Alzheimer’s disease mimic the function and gene expression patterns seen in patients’ brains.  Their results, published in Neuron, identify crucial shared pathways, confirming that the Alzheimer’s in a dish model can be used to assess new drugs accurately and rapidly as well as point the way to drug discovery. 

Concordia researchers report that acoustic features from the vocalisations made during the rutting season likely convey reliable information about male reindeers’ attractiveness or quality to potential mates.

These vocalisations are intended for both females and males, they note. The grunts of a rutting male indicate both their potential attractiveness to a mate and their maturity and strength to male rivals.

PHILADELPHIA — (Nov. 26, 2024) — The Wistar Institute’s Alessandro Gardini, Ph.D., and lab have shed new light on how certain biological processes determine the development of neural cells. Their findings on a molecular “bridge” complex demonstrate a new level of detail in the understanding of early neural development — which is fundamental for the further understanding of neurodevelopmental syndromes. The new paper, “The enhancer module of integrator controls cell identity and early neural fate commitment” was published in the journal, Nature Cell Biology.