Harvard physicists have developed a computational method that can uncover the rules that cells use to self-organize, translating the complex process of cell growth into an optimization problem a computer can solve.

The centromere is a unique chromosomal locus responsible for the faithful segregation of chromosomes during cell division. Disruption of centromere integrity frequently causes aberrant chromosome segregation and chromosome instability, a hallmark of cancers. The function of G9a/GLP-mediated H3K9me2 at (peri)centromeric heterochromatin remains elusive. A study published in Science Bulletin carefully investigated this topic and revealed an important role of H3K9me2 in protecting the centromeric chromatin landscape and thus ensuring accurate chromosome segregation.

Artificial intelligence (AI) is reshaping diverse fields in science, with molecular science being no exception. A recent study published in Research (Science Partner Journal) reports S²ALM, a powerful AI tool which uses a step-wise learning approach for a detailed analysis of antibodies. Using both 1D sequence and 3D structural data for antibody learning, the developed model outperforms prior models across key tasks, advancing antibody design for various diseases and redefining the future of therapeutic development.