CRISPR-based gene editing holds great promise, but off-target effects remain a major concern, especially across diverse genetic backgrounds. A new study presents a web-based tool that enhances off-target site prediction by incorporating individual genetic variants. Developed using the human genome and pepper plant cultivars, the tool improves accuracy at the haplotype level. This user-friendly, login-free platform offers researchers a powerful way to personalize and safeguard genome editing applications across fields.

Improved treatment regimens have increased the life expectancy of individuals infected with HIV. However, these individuals are at a higher risk of developing other comorbidities—one such condition that has been debated upon is osteoarthritis (OA). Now, researchers from Shanghai Jiaotong University have uncovered a link between protease inhibitors—drugs utilized in HIV management—and the acceleration of OA development.

A new study challenges the belief in a universal “pet effect” on human well-being. Using data collected during COVID-19 lockdowns, researchers found no significant change in respondents' well-being when they acquired or lost a pet in their household. The findings suggest that, even during a time of extreme isolation, human-animal bonds may not be as emotionally transformative as we like to believe.

It’s a debilitating disease that affects more than 500,000 Australians, but new research from the University of South Australia is offering fresh hope to people living with rheumatoid arthritis (RA).

The review highlights how disrupting the cell cycle, a process often hijacked by cancer cells for unchecked growth offers a promising strategy for cancer therapy. It focuses on drugs that precisely target key cell cycle regulators, several of which are already in clinical use. By showcasing the latest breakthroughs and outlining future research directions, the article provides a comprehensive look at how targeting cell cycle dysregulation is shaping the future of cancer care.