New “necroferrins” strategy targets both necroptosis and ferroptosis
Peer-Reviewed Publication
Updates every hour. Last Updated: 30-Oct-2026 21:16 ET (31-Oct-2026 01:16 GMT/UTC)
A new Review published in Ferroptosis and Oxidative Stress (FOS) explores whether a single class of molecules could simultaneously inhibit two interconnected forms of regulated cell death-necroptosis and ferroptosis-potentially opening new directions for therapeutic research.
High-resolution environmental DNA sampling reveals distinct spatiotemporal fish diversity dynamics and provides practical monitoring solutions for high-density cascade dam mountain rivers.
How similar are “joy” and “surprise”? Conversely, how far apart are “joy” and “sadness”?
We naturally organize words that express emotions—such as “happy,” “afraid,” and “angry”—according to similarities and differences in their meanings. However, investigating this entire structure using human participants alone is not easy, because the number of comparisons rises rapidly as more emotion terms are included.
Specially Appointed Assistant Professor Ke Han and Associate Professor Eiji Watanabe of the Laboratory of Neurophysiology, National Institute for Basic Biology (NIBB) investigated the semantic organization of emotion terms by asking GPT-4 to arrange those terms in a spatial layout and comparing the results with human judgments.
The results showed that prompting GPT-4 with a task in ordinary language reproduced a structure closely resembling the arrangements made by human participants. Moreover, when the vocabulary was expanded to 99 terms, a structure related to emotional intensity, or arousal, emerged that had been difficult to detect using only a small number of emotion terms. These research findings were published in Scientific Reports.
Recent advances in our understanding of human evolution challenge the way we currently name and classify our ancestors, according to new research from Monash University.
The research, published in the American Journal of Biological Anthropology, argues that we need a rethink, and proposes reclassifying all species of humans and our closely related fossil relatives that have lived in the past 4-5 million years as part of the Homo genus.
Human evolution is often presented as a straightforward progression through distinct species, from ape-like ancestors, through Australopithecus and earlier members of Homo, culminating in Homo Sapiens that live today.
Scientific progress comes not only from discovering something entirely new, but also from taking a fresh look at long-held assumptions. Now, a team at the University of Basel, Switzerland, challenges the decades-old view that coronin proteins primarily regulate the cytoskeleton.