Recently, a team led by Academician Hongjie Zhang, Researcher Shuyan Song, Associate Researcher Pengpeng Lei, and Dr. Ran An at the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, developed an innovative strategy to construct a series of biodegradable cesium nanosalts. These nanosalts activate anti-tumor immunity by inducing pyroptosis and metabolic intervention. The nanosalts induce ion endocytosis in tumor cells using a Trojan horse strategy, disrupting intracellular ion homeostasis, causing a surge in osmotic pressure, and ultimately triggering pyroptosis. Cesium ions (Cs⁺) can inhibit the ion channel activity of sodium/glucose cotransporters, hindering glucose transport. The introduction of docosahexaenoic acid (DHA) not only amplifies pyroptosis but also initiates immunogenic ferroptosis. The multiple effects of the nanosalts lead to the release of damage-related molecular patterns, thereby activating a robust anti-tumor immune response. The article was published as an open access research article in CCS Chemistry, the flagship journal of the Chinese Chemical Society.

In the development of Parkinson’s disease, it may not be a good idea to turn the amp to 11. High-volume noise exposure produced motor deficits in a mouse model of early-stage Parkinson’s disease, and established a link between the auditory processing and movement areas of the brain, according to a study published November 4^th in the open-access journal PLOS Biology by Pei Zhang from the Huazhong University of Science and Technology in Wuhan, China, and colleagues.