Ultrasound-responsive in situ antigen "nanocatchers" open a new paradigm for personalized tumor immunotherapy
Peer-Reviewed Publication
Updates every hour. Last Updated: 12-Jan-2026 00:11 ET (12-Jan-2026 05:11 GMT/UTC)
Professor Zhaohui Tang and Associate Professor Zhilin Liu from the team of Professor Xuesi Chen at the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, developed ultrasound-responsive in-situ antigen nanocatchers (S-nanocatchers), achieving precise spatiotemporal capture of tumor antigens and controllable acquisition of in-situ vaccines. This system solves the key problems of traditional antigen-capturing nanocarriers, such as their tendency to non-specifically bind to serum proteins during systemic circulation and their low antigen capture efficiency, providing a novel strategy for personalized tumor immunotherapy. The article was published as an open access Research Article in CCS Chemistry, the flagship journal of the Chinese Chemical Society.
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