The research group of Associate Professor Yasutomo Segawa and Assistant Professor Takashi Harimoto at the Institute for Molecular Science (National Institutes of Natural Sciences) and the Graduate University for Advanced Studies (SOKENDAI) has developed a new method for selectively synthesizing three-dimensional macrocycles,⁽¹⁾ in which four panels are arranged in a square, by connecting planar π-conjugated molecules⁽²⁾ at right angles.

This method is applicable to a wide variety of π-conjugated molecules and allows the size of the internal cavity to be designed. Furthermore, the resulting square macrocycles exhibit acid responsiveness, reversibly changing color under the action of a mild acid, while acid-mediated hydrolysis enables the starting monomers to be recovered in high yield—realizing a sustainable molecular synthesis that reverts to and regenerates the starting materials. The originality of this work lies in having a single imine bond⁽³⁾ play three roles: creating the shape, responding to stimuli, and reverting back.

These research results were published online in the Journal of the American Chemical Society, an international journal of the American Chemical Society, on Monday, June 1, 2026.

POSTECH Professor Sunmin Ryu’s team analyzes structural inhomogeneity in large-area thin films using interferometric SHG imaging.

A new study developed a mineralized DNA hydrogel that combines immune regulation with sustained bone regeneration. Using tetrahedral DNA nanostructures and calcium phosphate mineralization, researchers created a scaffold that promotes healing-friendly macrophage activity while supporting bone-forming stem cells. In animal models, the material accelerated bone repair, improved tissue mineralization, and prolonged structural stability. The findings may advance next-generation biomaterials for craniofacial reconstruction, traumatic injuries, and challenging bone healing disorders worldwide.

Carnegie’s Andrew Newman led a team of astronomers that used JWST to make  the first direct mass measurement of a dormant black hole at the center of a galaxy from the early universe. Previously, this technique had only been used to study black holes in the local universe. But JWST and a phenomenon called gravitational lensing enabled the researchers to use it on a galaxy that's light is reaching us from when the universe was just 3 billion years old.