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Template-assisted synthesis dramatically improves the yield of functionalized oligophenylene cages, report researchers from Japan. By using covalent templates to guide a six-fold Suzuki–Miyaura cross-coupling reaction, the researchers achieved significantly higher yields of around 68% in comparison to conventional methods, which struggle to exceed a 10% yield. The resulting molecular cages feature tailored cavities with inward-facing OH and NH2 groups for selective molecular encapsulation—opening new avenues for host-guest chemistry and catalysis.