A CSU team has measured a hydrogen proton’s radius to be 0.84 femtometers, resolving a long-standing scientific discrepancy known as the proton radius puzzle. The ultra-precise measurement further confirms the foundational Standard Model, which governs the behavior of subatomic particles across the known universe. 

Researchers at IRB Barcelona develop a computational framework that creates molecules with selective activity in specific cell types, without the need to start from a predefined molecular target.

Published in Communications Chemistry, the new strategy combines predictive and generative AI to design new chemical entities with specific biological effects.

Experimental validation confirmed that several of the AI-generated molecules displayed the activity they were designed for, achieving a success rate superior to that of traditional screening methods.

Cytochrome P450 enzymes are promising biocatalysts for greener chemical manufacturing, but many remain difficult to study because their activity relies on unidentified partner proteins. Now, researchers from Japan have engineered the P450 enzyme CYP107J1 from Bacillus subtilis into a new hydrogen peroxide-driven form that no longer requires these partners. The modified enzyme exhibited 28-fold higher catalytic activity than its natural counterpart and efficiently produced indigo dye, demonstrating a promising strategy towards sustainable oxidation chemistry.