We present a one-step, visible light-induced synthesis of bicyclo[1.1.1]pentane-ketone, a bioisostere for benzoyl groups that enhances drug properties. This method operates under mild conditions, tolerates oxidation-sensitive substituents, and achieves moderate to high yields. Mechanistic studies indicate the necessity of stoichiometric ^tBuOOH despite the reaction’s redox-neutral nature. This approach offers a streamlined strategy for incorporating bicyclo[1.1.1]pentane-ketone into pharmaceuticals, potentially improving their efficacy and compatibility.

At CERN, the European Organisation for Nuclear Research in Geneva, an international research team led by the Paul Scherrer Institute PSI has conducted especially precise measurements of atmospheric chemistry. Through this study the researchers were able to show how harmful particulate matter arises from vehicular emissions and biomass combustion. Their findings are helping to make existing models of particle formation more accurate.

Kyoto, Japan -- The Mpemba effect, in which hot systems cool faster than cold ones under the same conditions, was first described by Aristotle more than 2,000 years ago. In 1963 it was rediscovered by Tanzanian student Erasto Mpemba, who observed it when preparing ice cream in a cooking class at school. Mpemba later collaborated with British physicist Denis Osborne on a paper that described its effect on water.

Since Mpemba and Osborne's influential research, further studies have demonstrated that the effect extends beyond simple liquids and can be observed in a variety of physical systems --even microscopic ones. Yet one fundamental challenge has persisted; the detection of the Mpemba effect depends on the choice of a specific distance measure.

An infinite number of distance measures exist, so observing the effect using one distance measure may not materialize within a finite time when evaluated with another. Conventional methods typically assess relaxation speed, which is the rate of return to equilibrium after a change in temperature -- by using a single monotone measure -- but this often leads to inconsistent results.

Researchers develop new sensor to detect dangerous gas leaks in lithium-ion batteries

Researchers have engineered yeast to efficiently convert methanol into D-lactic acid, a key compound for biodegradable plastics and pharmaceuticals. By optimizing gene and promoter combinations, they achieved the highest reported yield to date, offering a sustainable alternative to petroleum-based production. Their findings advance eco-friendly chemical manufacturing.