Article Highlights
Updates every hour. Last Updated: 8-Apr-2026 11:16 ET (8-Apr-2026 15:16 GMT/UTC)
How insulin resistance drives polycystic ovary syndrome
Shanghai Jiao Tong University Journal CenterPolycystic ovary syndrome (PCOS) is a common gynecological disease that affects women of reproductive age and is characterized by hyperandrogenism, ovulatory dysfunction, and polycystic changes in the ovaries. In recent years, along with irregular menstruation and infertility, metabolic abnormalities associated with PCOS have garnered increasing attention. Insulin resistance is the most prevalent metabolic abnormality in patients with PCOS and is closely related to disease progression and severity.
- Journal
- Reproductive and Developmental Medicine
Review summarizes metabolomic advances in endometriosis research
Shanghai Jiao Tong University Journal CenterDespite impressive progress being made in investigating the mechanisms underlying endometriosis, the pathophysiology of this disease remains unclear. Although typical methods used for diagnosing endometriosis such as ultrasound, magnetic resonance imaging, and blood tests are available, these are also inefficient, and effective noninvasive diagnostic methods are lacking. The advances in high-throughput omics techniques have enabled metabolomics to become an effective approach for discovering promising biomarkers. The aberrant metabolism associated with serious symptoms of endometriosis in women has been revealed in recent years. Analyzing the global metabolic patterns in patients with endometriosis may help deepen the understanding of the disease mechanism and have a significant impact on future diagnostic and treatment methods for endometriosis. Herein, we reviewed relevant studies on metabolic changes in patients with endometriosis and discussed the changes in metabolites both in biological fluids and endometriosis tissues. The findings discussed in this review have potential diagnostic implications and will enhance the understanding of the pathophysiological processes underlying the disease.
- Journal
- Reproductive and Developmental Medicine
Landmark study reveals critical link between depression and metabolic health
Shanghai Jiao Tong University Journal CenterNumerous studies have consistently demonstrated that a considerable proportion of patients with major depressive disorder (MDD) frequently exhibit pronounced dyslipidaemia. However, the causal dynamics between MDD and dyslipidaemia remain elusive. To comprehensively disentangle the genetic causality between MDD and various phenotypes of blood lipids, thereby facilitating the advancement of management strategies for these conditions.
- Journal
- General Psychiatry
Turning Australia’s food waste into biochar: a sustainable solution for climate and soil
Biochar Editorial Office, Shenyang Agricultural University- Journal
- Carbon Research
Broad-spectrum virus elimination by nasal mucosa-colonized wild-type Bacillus subtilis
ResearchA research team at Nanjing Agricultural University has identified a wild-type strain of Bacillus subtilis (NS12) isolated from the nasal mucosa of outdoor pigs, which demonstrates remarkable ability to colonize mucosal surfaces and directly block viral infections.
- Journal
- Research
- Funder
- National Key Research and Development Program of China, National Natural Science Foundation of China, Natural Science Foundation of Jiangsu Province, Fundamental Research Funds for the Central Universities, China Postdoctoral Science Foundation funded project, Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Researchers uncover early molecular signatures of type 2 diabetes in prediabetic rats
Osaka Metropolitan UniversityResearchers at Osaka Metropolitan University uncovered early hepatic changes associated with type 2 diabetes by analyzing primary hepatocytes from prediabetic Otsuka Long-Evans Tokushima Fatty rats.
- Journal
- Bioscience Biotechnology and Biochemistry
University hospitals research published in New England Journal of Medicine shows durability of limb salvage therapy for no-option amputation patients
University Hospitals Cleveland Medical Center- Journal
- New England Journal of Medicine
A major new review on single-cell multi-omics data integration
Higher Education Press- Journal
- Quantitative Biology
Low acceptance of self-help education during public emergencies among older migrants in China’s mainland
Higher Education PressA study of 5,840 older adult migrants in China’s mainland revealed that only 19.9% had received education for self-help in public emergencies. Participation was lower among those aged over 75, long-term migrants, rural residents, individuals with lower education levels, those migrating for family or social reasons, and people without established health records. Researchers stress the need for targeted education strategies, such as online platforms and tailored community programs, to improve preparedness in this vulnerable group.
- Journal
- Healthcare and Rehabilitation