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Updates every hour. Last Updated: 20-Aug-2025 14:10 ET (20-Aug-2025 18:10 GMT/UTC)
New AI system could change how autonomous vehicles navigate without GPS
University of Surrey- Journal
- IEEE Robotics and Automation Letters
Pedunculoside promotes oral ulcer healing in mice by upregulating STAT3 and Smad3
Journal of Dermatologic Science and Cosmetic TechnologyThis study investigates the effect of Pedunculoside (PE) on ulcer recovery using a murine oral ulcer model and in vitro assays with primary oral mucosal fibroblasts.
In vivo, PE treatment significantly accelerated ulcer healing in mice, achieving a 7-day cure rate of 85.7%, which is notably higher than control groups. In vitro, PE promoted fibroblast proliferation and markedly enhanced collagen secretion—both key processes in wound healing. Gene and protein expression analyses revealed that PE significantly upregulated Smad3, Col1a1, and Col3a1, indicating a stimulation of the collagen synthesis pathway. Importantly, PE reversed the inhibitory effects of WP1066 (a STAT3 inhibitor) on STAT3 activation, suggesting that PE exerts its healing effects through STAT3 and Smad3 signaling axes.
While PE did not affect fibroblast migration, its potent effect on proliferation and collagen production positions it as a compelling candidate for oral ulcer therapy. These findings provide a pharmacological foundation for the development of PE as a natural and effective agent for treating oral mucosal injuries. Moreover, this study sheds light on the molecular mechanisms of wound healing, emphasizing the relevance of STAT3 and Smad3 signaling in the regenerative process.
Given its anti-inflammatory and pro-healing properties, PE may offer a safe, low-cost alternative or complementary therapy for oral ulcers, particularly in populations seeking herbal or traditional treatments.
- Journal
- Journal of Dermatologic Science and Cosmetic Technology
Does meditation come with side effects?
Association for Psychological Science- Journal
- Clinical Psychological Science
Catalysts provide the right pathway to green energy
King Abdullah University of Science & Technology (KAUST)- Journal
- Journal of the American Chemical Society
Study: Multiracial women at greater risk of bipolar disorder during the perinatal period
University of Illinois at Urbana-Champaign, News Bureau- Journal
- Frontiers in Psychiatry
PolyU survey reveals over 40 per cent of family caregivers in Hong Kong have mental health issues, advocating data-driven tool to improve social welfare policy
The Hong Kong Polytechnic University- Journal
- Health and Quality of Life Outcomes
Grimm classics counter negative effects of internet browsing
JMIR Publications- Journal
- JMIR Formative Research
Rarefaction-induced non-equilibrium characteristics in shock wave/boundary layer interaction
Tsinghua University PressShock wave/boundary layer interaction (SWBLI) has long been a challenge in compressible flow simulations due to its complex multi-scale and non-equilibrium characteristics. Particularly, the simulation of multi-scale SWBLI under near-space conditions poses significant challenges to traditional continuum models such as the Navier–Stokes (NS) equations. To address this, researchers employed a mesoscopic Discrete Boltzmann Method (DBM) to investigate the discrete effects and non-equilibrium behaviors in SWBLI which are beyond the NS description. Given that different interfaces such as temperature and density will provide different characteristic scales, correspondingly, will provide local Knudsen (Kn) numbers of different perspectives. From one perspective, the Kn number is increasing, but from another perspective, it may be decreasing. Therefore, the early understanding based on the definition of the Kn number from a single perspective was one-sided or even wrong. Therefore, researchers proposed the concept of the local Kn number vector: each component of it is a Kn number from one perspective. Based on the developed DBM theory and method, they discovered a series of kinetic features and new mechanisms in rarefied laminar SWBLI.
- Journal
- Chinese Journal of Aeronautics
Variable drooping leading edge: Flexible aerodynamic design boosts aircraft ice tolerance for commercial jets
Tsinghua University PressBy focusing on adaptive aerodynamics, the ice-tolerance concept with variable drooping leading edge technology could revolutionize how planes handle icing skies. An ice tolerance solution based on the variable camber leading edge of iced wings is proposed, where the leading edge adapts its camber to counter ice effects. Compared with traditional aerodynamic design for ice tolerance, this concept not only strikes a balance between safety and functionality, but also boosts efficiency even under severe icing conditions.
- Journal
- Chinese Journal of Aeronautics