Chemotherapy-induced nausea and vomiting (CINV) represents one of the most distressing and debilitating side effects experienced by cancer patients undergoing treatment, significantly impacting quality of life, treatment adherence, and overall therapeutic outcomes. Neurokinin-1 receptor antagonists (NK1RAs) have emerged as cornerstone agents in the modern management of CINV, particularly for delayed-phase symptoms that occur 24-120 hours after chemotherapy administration. These agents target substance P binding to NK-1 receptors in both central and peripheral nervous system pathways, addressing the complex neurotransmitter mechanisms underlying CINV pathophysiology.

Hydrogen sulfide (H₂S)-based mitochondrial energy metabolism blockade is an attractive tumor therapeutic modality. However, it is limited owing to metabolic plasticity, which allows tumors to shift their metabolic phenotype between oxidative phosphorylation and glycolysis for energy compensation. Herein, a hollow-hierarchical H₂S-multistage blasting nanomedicine was designed for a dual-pathway strategy targeting the blockade of energy metabolism and the imbalance of redox homeostasis. Achieved acidic and high glutathione (GSH)-responsive cascade release, presenting a long-term blast of in situ H₂S and calcium overload, coupled with in situ Prussian blue with heat-enhanced peroxidase enzyme activity and loaded glucose oxidase with H₂O₂ self-supply properties, thus exacerbating mitochondrial dysfunction in multiple pathways, disrupting intracellular redox homeostasis, and completely blocking the tumor cell's energy supply of tumor cells. This dual-pathway strategy utilizes H₂S gas-calcium overload to block energy metabolism and induce redox imbalance, providing new insights into exploring energy metabolism blockade as a therapeutic tool for tumor therapy.

Triboelectric nanogenerators (TENGs) are emerging devices with the ability to harvest energy in the environment. TENG usually consists of electrode and polymer layer, and the electrode could use the recyclable materials. However, the polymers commonly used in TENG, such as polydimethylsiloxane (PDMS), Kapton, and so on, which are difficult to degrade completely and prone to release dangerous chemicals in the natural environment. Due to the abundant sources, low cost, and biodegradability, natural biomaterials as friction layers for developing the degradable TENG have attracted considerable attention. However, achieving high electrical output performance and degradability simultaneously in a TENG remains challenging.

Researchers developed a self-assembly, carrier-free prodrug nanoplatform with dual PEGylation and tumor cell membrane coating. The system exhibits high drug loading, strong tumor selectivity, and long in vivo circulation, offering a promising solution to the long-standing challenges of stability and specificity in cancer nanomedicine.

The new release work in Nano Research reveals the critical role of initial lattice distortion (quantified by atomic size difference, δ) in defect formation and capacity decay of vanadium (V)-based alloys. High-δ alloys exhibited greater hydrogen capacity loss, accompanied by increased plateau slopes (S_f) and defect concentrations High-resolution microscopy uncovered a two-stage defect evolution in high-δ alloys: (1) misoriented nanograins formed at the first cycle, generating dislocations; (2) alternating layered nanostructures emerged in subsequent cycles, creating subgrain boundaries and localized strain. Notably, low-δ alloys avoided layered structure formation. These findings propose a design principle—minimizing δ—to develop stable hydrogen storage alloys.

A liquid alloy (GaInSn)-coated Cu substrate (LM@Cu) addresses K anode instability and dendrites via enhanced potassiophilicity, reduced nucleation overpotential, and self-diffusive planar growth, enabling uniform K deposition. Paired with a PTCDI cathode, the battery delivers 124.4 mAh g⁻¹ initially and retains 78.2 mAh g⁻¹ after 4900 cycles at 500 mA g⁻¹, demonstrating LM@Cu's viability for durable K-metal batteries.

Radioactive iodine gas detection has significant applications in the nuclear industry, particularly in nuclear accident scenarios and nuclear fuel reprocessing facilities. Metal-organic frameworks (MOFs), owing to their high specific surface area, large pore volume and structurally tunable nature, hold great promise as sensing materials for the electrical detection of iodine gas, by combining with impedance spectroscopy techniques.

The detection of circularly polarized light (CPL) is crucial for various emerging technologies such as communication, information processing, and photoelectronic devices. However, the widespread use of lead-based materials in CPL detection poses environmental concerns. A research team led by Ruosheng Zeng from Guangxi University has synthesized a zero-dimensional (0D) lead-free chiral antimony-based halide, (R/S-MBA)₄Sb₂Br₁₀, which exhibits strong polarity and crystallographic chirality. This material shows great potential for high-sensitivity self-powered CPL detection, nonlinear optics, and chiral-induced spin selectivity effects (CISS), offering a new approach for the development of environmentally friendly optoelectronic devices.

Macrocycles serve as key building blocks for mechanically interlocked molecules. Incorporating novel macrocyclic motifs into interlocked topologies not only expands structural diversity but also unlocks emergent properties. This review summarizes mechanically interlocked molecules consisting of radially conjugated macrocycles, highlighting their innovative structural designs and synthetic approaches from a topological perspective.