18-Oct-2025 Evolution-assisted engineering boosts succinic acid production in E. coli Nanjing Agricultural University The Academy of Science A research team has successfully combined adaptive laboratory evolution (ALE) with metabolic engineering to create a strain of Escherichia coli that produces succinic acid (SA) from glycerol at significantly higher yields. Journal BioDesign Research
18-Oct-2025 Engineered yeast unlocks sustainable production of cannabinoids and analogs Nanjing Agricultural University The Academy of Science A research team has engineered the nonconventional yeast Yarrowia lipolytica to produce cannabinoids and their analogs, offering a sustainable alternative to plant extraction. Journal BioDesign Research
18-Oct-2025 Boosting production of pharmacologically relevant diterpenoids through engineered miltiradiene synthase Nanjing Agricultural University The Academy of Science A team of researchers has uncovered how subtle structural changes in terpene synthases can dramatically improve the biosynthesis of miltiradiene, a critical intermediate in the production of pharmacologically valuable compounds such as tanshinone IIA, triptolide, and carnosic acid. Journal BioDesign Research
18-Oct-2025 Yeast-engineered biocatalysis enables stepwise production of MDMA and analogs Nanjing Agricultural University The Academy of Science A research team has developed the first reported bioproduction method for 3,4-methylenedioxymethamphetamine (MDMA, commonly known as Ecstasy) and related methamphetamine derivatives using a combination of yeast-based bioconversion, biocatalysis, and chemical reduction. Journal BioDesign Research
18-Oct-2025 Protein engineering advances unlock pathways to greener industrial biocatalysts Nanjing Agricultural University The Academy of Science A research team has summarized the latest advances in protein engineering strategies aimed at enhancing enzyme stability under harsh industrial conditions. Journal BioDesign Research
18-Oct-2025 An acoustofluidic device for sample preparation and detection of small extracellular vesicles Beijing Institute of Technology Press Co., Ltd A research paper by scientists at Duke University School of Medicine presented a novel sharp-edge acoustofluidic platform designed for rapid and effective sample preparation, coupled with sensitive detection of specific sEV populations based on their surface markers.. The research paper, published on Jul. 17, 2025 in the journal Cyborg and Bionic Systems.
17-Oct-2025 Advancing CO2 conversion: Innovations in carbonaceous-supported catalysts Biochar Editorial Office, Shenyang Agricultural University In a significant advancement in sustainable chemistry, researchers are exploring cutting-edge developments in carbonaceous-supported catalysts for converting CO2 into cyclic carbonates. The study, titled "C4C Recent Developments: Carbonaceous-Supported Catalysts for CO2 Conversion into Cyclic Carbonates," is led by Prof. Nader Ghaffari Khaligh from the Nanotechnology and Catalysis Research Center at the Institute for Advanced Studies (IAS), Universiti Malaya in Kuala Lumpur, Malaysia. This research offers a detailed exploration of innovative catalysts that promise to transform CO2 into valuable chemicals, driving progress in sustainable chemistry. Journal Carbon Research
17-Oct-2025 Dynamics of epithelial–mesenchymal plasticity driving cancer drug resistance Chinese Medical Journals Publishing House Co., Ltd. This review demonstrates that epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET) drive cancer metastasis and drug resistance, regulated by signaling pathways, the tumor microenvironment (TME), and epithelial/mesenchymal (E/M) plasticity. Its innovation lies in linking E/M states to therapy resistance; clinically, targeting EMT or related pathways may enhance chemotherapy and immunotherapy efficacy. Journal Cancer Pathogenesis and Therapy
17-Oct-2025 Phytoconstituents as emerging therapeutics for breast cancer: Mechanistic insights and clinical implications Chinese Medical Journals Publishing House Co., Ltd. This review highlights phytoconstituents’ multitargeted anti-breast cancer effects (apoptosis induction, angiogenesis/metastasis suppression) with preclinical/clinical evidence. Innovations include nanodelivery; clinical insights: combine with conventional therapies to overcome resistance, reduce toxicity, and address bioavailability issues. Journal Cancer Pathogenesis and Therapy
