Insilico Medicine (“Insilico”; HKEX: 3696), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, today announced Longevity Vaccines, a research initiative developing treatments that direct a patient’s own immune cells to eliminate the earliest cellular drivers of age-related disease. This initiative expands the company’s dual-purpose, aging-oriented discovery strategy from small molecules into RNA-encoded, in vivo cell engineering. 

Non-fatal overdoses happen far more often than fatal overdoses, yet little is known about where they occur. A study of 1,661 non-fatal overdoses in Palm Beach County found that nearly half of mapped overdose hotspots significantly overlapped with gas stations, while others followed major transportation corridors. Nearly 40% of overdoses occurred outdoors, with outdoor overdoses strongly associated with housing instability, lack of insurance and younger age. People experiencing housing instability had five times the odds of overdosing near a gas station, offering new opportunities for targeted, place-based prevention.

Published in the International Journal of Extreme Manufacturing, researchers improved the balance of strength and ductility by using laser powder bed fusion to create alternating coarse- and fine-grained regions in a zinc–copper alloy.

Patients with major depressive disorder (MDD) and an inadequate response to standard antidepressants who received an add- on treatment with the drug lumateperone saw significantly improved sexual function, found a new study led by a University of Virginia School of Medicine researcher. 

In two Indigenous communities living pre-industrial lifestyles in the Bolivian Amazon, dementia is remarkably uncommon. However, a new longitudinal study reveals why earlier estimates told only part of the story.

Among the Tsimané and Mosetén communities, dementia incidence, or the rate of new cases, didn’t dramatically differ from rates in U.S. and northern European populations, especially for individuals under 80 years old. Shorter survival after dementia develops appears to play a significant role in why dementia prevalence – the total proportion of people living with the disease at a given time – in the Tsimané and Mosetén populations is unusually low.

“The surprising finding was that there weren’t big differences in dementia incidence,” said lead author Margaret Gatz, a professor of psychology and gerontology at USC and a senior scientist at the USC Center for Economic and Social Research. “That challenges us to identify the risk factors for developing dementia in the Tsimané population.”