Scientists develop test that predicts which patients will not respond to cancer chemotherapy
Peer-Reviewed Publication
Updates every hour. Last Updated: 15-Aug-2025 03:10 ET (15-Aug-2025 07:10 GMT/UTC)
The use of this test in clinical practice would allow for the avoidance of side effects and the implementation of more effective treatment. "We've found a way to practice precision medicine with standard chemotherapy," says Geoff Macintyre, a researcher at the Spanish National Cancer Research Centre (CNIO). The research has been published in the journal Nature Genetics. The test will now be validated in a hospital setting, thanks to a new project funded by the Spanish Ministry for Digital Transformation and Public Service.
Cancer Research UK-funded scientists at the University of Cambridge create a test to predict resistance to chemotherapy. The test uses changes to cancer DNA at diagnosis to predict which patients will be resistant to three common types of chemotherapy. New method could benefit thousands of patients every year by helping them avoid treatments that are less likely to benefit them.
A team led by Prof. Zhenke Zhu from Ningbo University analyzed 261 soil samples across China to systematically compare the impacts of different legume crop rotations on soil properties and microbial communities, revealing the unique advantages of faba bean (Vicia faba) rotation in enhancing soil multifunctionality and its microbial-driven mechanisms. The relevant paper has been published in Frontiers of Agricultural Science and Engineering (DOI: 10.15302/J-FASE-2025604).
In a paper published in MedComm – Future Medicine, a Chinese research team presents ImmunoCheckDB, a comprehensive web platform integrating meta-analysis and multiomic data to discover cancer immunotherapy biomarkers. The platform curates 173 studies on immune checkpoint inhibitor (ICI) therapies, covering survival outcomes for 93,234 individuals across 18 cancer types and 30 ICI regimens, enabling pan-cancer exploration of molecular markers for ICI efficacy.
Advances in wearable electronics and information technology drive sports data collection and analysis toward real-time visualization and precision. The growing pursuit of athleticism and healthy life makes it appealing for individuals to track their real-time health and exercise data seamlessly. While numerous devices enable sports and health monitoring, maintaining comfort over long periods remains a considerable challenge, especially in high-intensity and sweaty sports scenarios. Textiles, with their breathability, deformability, and moisture-wicking abilities, ensure exceptional comfort during prolonged wear, making them ideal for wearable platforms. This review summarized the progress of research on textile-based sports monitoring devices. First, the design principles and fabrication methods of smart textiles were introduced systematically. Textiles undergo a distinctive fiber–yarn–fabric or fiber–fabric manufacturing process that allows for the regulation of performance and the integration of functional elements at every step. Then, the performance requirements for precise sports data collection of smart textiles, including main vital signs, joint movement, and data transmission, were discussed. Lastly, the applications of smart textiles in various sports scenarios are demonstrated. Additionally, the review provides an in-depth analysis of the emerging challenges, strategies, and opportunities for the research and development of sports-oriented smart textiles. Smart textiles not only maintain comfort and accuracy in sports, but also serve as inexpensive and efficient information-gathering terminals. Therefore, developing multifunctional, cost-effective textile-based systems for personalized sports and healthcare is a pressing need for the future of intelligent sports.
An Osaka Metropolitan University research team assessed whether the use of 5-aminosalicylic acid during vedolizumab treatment helps prevent relapse in ulcerative colitis and Crohn’s disease.