Like all hardworking things, the cytotoxic T lymphocytes (CTLs) of the immune system charged with detecting and destroying cancer cells tend to get very tired—so much so, in fact, that they can even die from exhaustion.

BUFFALO, NY – November 17, 2025 – A new research perspective was published in Oncotarget (Volume 16) on November 14, 2025, titled “A personal perspective of patient-centred clinical trials.”

Researchers at The University of Osaka developed the Balloon-Assisted Bronchoscope Delivery (BDBD) technique and in a first-in-human clinical trial, the team successfully demonstrated that this technique is both safe and effective, enabling access to lesions smaller than 20 mm. By using a small balloon to gently widen airways, it allows endoscopes to reach deep, peripheral lung tumors, promising more accurate cancer diagnosis and new minimally invasive treatment options.

A new Northwestern Medicine study introduces a first-of-its-kind online calculator that uses percentiles to help younger adults forecast and understand their risk of a heart event over the next 30 years. With rates of obesity, diabetes and hypertension rising among younger Americans, the study authors say identifying long-term risk earlier could help bend the curve on future heart disease, the leading cause of death in the U.S. and worldwide.