Early-stage clinical trial demonstrates promise of intranasal influenza vaccine in generating broad immunity
Peer-Reviewed Publication
Updates every hour. Last Updated: 21-Dec-2025 20:11 ET (22-Dec-2025 01:11 GMT/UTC)
Researchers at the University of Maryland School of Medicine’s Center for Vaccine Development and Global Health (CVD) reported encouraging results from an early phase clinical trial that found an experimental intranasal vaccine triggered a broad immune response against multiple strains of H5N1 “bird flu”. The study, published today in the journal Nature Communications, [DK1] highlights the potential of mucosal immunization strategies--where vaccines are sprayed into the nostrils--to prime immune defenses against diverse influenza strains.
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