Apples owe much of their health value to polyphenols—natural antioxidants that fight oxidative stress and chronic diseases. Yet centuries of domestication have quietly diminished these compounds in today’s sweeter, larger fruits. A research team has now traced this nutritional loss to a specific genetic mechanism. By integrating genome-wide association analysis with molecular experiments, they uncovered a powerful regulatory pair—MdDof2.4 and MdPAT10—that triggers the accumulation of procyanidins, the most abundant polyphenols in apples. The discovery reveals how a tiny promoter insertion reawakens a dormant metabolic pathway, opening a path toward breeding apples that are both delicious and rich in health-promoting compounds.

Kyoto, Japan -- For people with medical conditions, stigma is a real problem they must worry about on top of their health. Stereotypes about health conditions often cause discrimination even by healthcare providers, as many may assume those affected don't take care of their health, when in reality they likely have no control over their condition.

Diabetes affects nearly ten percent of the global adult population and causes almost two million deaths per year, yet the persistent stigma surrounding people with the disease is a global concern. Physicians may act as inadvertent perpetrators, but their level of awareness is still poorly understood.

To address this, it is essential to gauge the level of awareness of a diabetes stigma among future physicians and identify the need for strategic interventions in medical education. This approach motivated a team of researchers at Kyoto University to first assess awareness of stigma and advocacy among medical students in Japan.