PGK1 lactylation-driven self-reinforcing loop orchestrates glycolytic reprogramming in FSP1+ macrophages in liver fibrosis
Peer-Reviewed Publication
Updates every hour. Last Updated: 31-Oct-2026 17:16 ET (31-Oct-2026 21:16 GMT/UTC)
FSP1 (fibroblastspecific protein 1) was originally considered a marker of fibroblasts, but recent studies have confirmed that it is primarily expressed by a proinflammatory macrophage subset in liver injury and participates in the regulation of inflammation and fibrosis. This study systematically explores the interplay among these three elements.
Polymer-based flexible wireless sensors have demonstrated significant potential in health monitoring. However, existing studies have predominantly focused on material design, energy harvesting, and wireless communication, while research addressing signal attenuation, noise accumulation, and data distortion within wireless links remains relatively limited. Physiological signals are highly susceptible to multi-source interference during acquisition and transmission; without effective data processing and intelligent analysis strategies, monitoring outcomes may fail to meet the accuracy and stability requirements of clinical applications. To address this research gap, this review constructs a comprehensive framework encompassing signal sensing, link transmission, and intelligent processing, building on advances in flexible materials and wireless energy supply modes. Special attention is given to the critical roles of channel compensation, noise suppression, feature extraction, lightweight artificial intelligence models, and edge computing in enhancing data quality and reducing energy consumption. Furthermore, the review systematically analyzes the impact of wireless link stability and energy management on monitoring performance. By reinforcing the synergistic mechanisms between data processing and communication, this work aims to provide design principles and development directions for the next generation of high-reliability, low-power, and intelligent wireless flexible health monitoring systems.
San Francisco, CA (July 15, 2026) – Today, UCSF Health, Kleiner Perkins and Doerr Capital announced UCSF Health Converge, a new health AI accelerator that brings select companies together with clinicians, operators and technology leaders inside a nationally-ranked academic health systems to build, validate, and scale AI solutions in real care delivery settings.
A condition affecting approximately 170 million adolescents and women worldwide has a new name – one that better reflects its complexity and far-reaching health impacts.
Polycystic ovary syndrome, PCOS, has long been understood as a reproductive disorder. But a recent paper published in The Lancet proposes renaming it polyendocrine metabolic ovarian syndrome, PMOS, to more accurately capture what researchers now know about the condition: it is not just about the ovaries, but about the entire body.