In a comprehensive review published in Research, investigators from Zhongda Hospital, School of Medicine, Southeast University propose an integrative framework centered on EG to explain this shift from defense to dysfunction. The authors synthesize evidence across single-cell multi-omics, bone-marrow niche remodeling, and immunometabolic reprogramming. By integrating single-cell biology with bedside indicators, this work clarifies why a protective program becomes maladaptive and outlines practical avenues for biomarker-guided stratification.

A new Cochrane review has found that sucrose can help with pain relief in newborn babies during common hospital procedures, such as venepuncture. This involves drawing blood with a needle, typically for testing.

 Newly published research by Cleveland Clinic and Dyania Health demonstrates how a medically trained large language model system can accurately and efficiently screen electronic medical records (EMRs) to identify patients who are eligible for a rare disease clinical trial.

Published in The Journal of Cardiac Failure, the official journal of the Heart Failure Society of America, the study offers real-world evidence that artificial intelligence (AI)-enabled medical chart review can improve the speed, accuracy and equity of trial enrollment.