This review article provides a comprehensive overview of stress granules (SGs) —membraneless organelles formed in response to cellular stress—and their interactions with other organelles. It explores their structure, function, roles in health and disease, especially neurodegeneration, and discusses methodologies used to study these interactions. SGs influence critical cellular pathways, and understanding their interplay with both membrane-bound and membraneless organelles can reveal potential therapeutic targets for diseases like ALS and FTD.

New research found that combining radiofrequency ablation (RFA) with anti-PD-1 immunotherapy provides dual therapeutic benefits for hepatocellular carcinoma (HCC), effectively controlling distant tumors while preventing recurrence. The combination therapy significantly enhances infiltration of CD8⁺ T cells and dendritic cells while reducing PMN-MDSCs, mediated through activation of CXCL10/JAK-STAT signaling pathways. Importantly, this approach establishes durable immune memory capable of inhibiting growth of rechallenge tumor.

People who have survived cancer as children are at higher risk of developing severe COVID-19, even decades after their diagnosis. This is shown by a new study from Karolinska Institutet published in the journal The Lancet Regional Health – Europe.

At the invitation of Professor Sergio Bernardini, Secretary General of the International Society of Clinical Chemistry and Laboratory Medicine (IFCC) and Deputy Editor-in-Chief of LMD, the LMD team appeared at the 2025 IFCC Annual Meeting in Brussels, Belgium. There, they jointly exhibited with international authoritative journals such as Clinica Chimica Acta and Journal of Mass Spectrometry & Advances in the Clinical Lab, jointly creating a high-end academic platform in the field of laboratory medicine.

India’s race, religion, and caste are quite diverse. Even within the same nation, regional variations exist in the ABO blood type and the Rh system. The current research examined the relationship between diseases and the ABO blood type among Nagaland’s Chakhesang ethnic communities. This research considered the population of sick people with ABO blood types. One hundred persons, including men and women from the Chakhesang tribe, served as research respondents. The Chakhesang Naga tribe was selected for this study because of the documented higher prevalence of hypertension and diabetes mellitus within this group compared to the broader regional population. The study also aimed to explore a possible association between these health conditions and blood type A. The ABD antisera typing Kit’s standard methodology was followed for blood group testing. S2 ABO software was used to compute the Hardy-Weinberg model, and the chi-square test was used to compare the results. In this research, we discovered that blood type A was more likely to develop hypertension and diabetes than blood types B and O (blood type A, X² = 16.3, P = 0.00∗; blood type B, X² = 18, P = 0.00∗; blood type O, X² = 0.085, P = 0.87). This might imply that blood type A may be genetically predisposed to diabetes and hypertension more than other blood types. Our research shows that, compared to healthy individuals, the prevalence of hypertension and diabetes was much higher in the general population. The Chakhesang Naga tribe has the highest prevalence of blood type B, while those with blood type A are the most afflicted and sensitive to hypertension and diabetes. A key limitation of the study is that the findings are based on a specific population and may not be generalizable. Larger and more diverse cohorts are needed to evaluate their broader applicability.

Non-invasive respiratory support has transformed the treatment of acute hypoxemic respiratory failure, yet choosing the best option remains challenging. A special issue of the Journal of Intensive Medicine explores currently available strategies and their roles in improving patient outcomes and avoiding intubation. Through both expert reviews and original research, this special issue offers practical, evidence-based guidance to help medical practitioners navigate a critical aspect of intensive care.