Mechanical forces: The hidden conductor shaping organoids and organs-on-chips
Peer-Reviewed Publication
Updates every hour. Last Updated: 31-Oct-2026 17:16 ET (31-Oct-2026 21:16 GMT/UTC)
A comprehensive review published in Nano Research reveals how mechanical forces—such as fluid shear, matrix stiffness, and cyclic strain—are essential for building realistic organoids and organ-on-a-chip models. The work bridges mechanobiology and microengineering, offering a roadmap for designing next-generation in vitro systems that truly mimic human physiology. These advances could revolutionize drug screening, disease modeling, and personalized medicine.
A Dartmouth study finds that AI may cost doctors time when corresponding with patients by making them spend more time editing AI-drafted responses than it would take to write them. The researchers analyzed 146,000 conversations between patients and their primary care physicians from the online portal of a large healthcare system and found that automated responses frequently introduced errors and extraneous details. But the study provides a framework for generating "good" AI responses that align with how clinicians communicate and shows that adapting AI to individual physicians can reduce editing by 26%. The study was presented at the 64th Annual Meeting of the Association for Computational Linguistics.
The Vaccine Innovation Center at Korea University College of Medicine has been selected by the Korea Disease Control and Prevention Agency (KDCA) as the lead institution for a national hantavirus vaccine development project.
The initiative is part of the Korean government’s strategic efforts to establish a rapid-response vaccine development system capable of producing vaccine prototypes within 200 days of the emergence of a future pandemic. The Center will oversee the overall project, working in collaboration with biotechnology companies.
Hiroshima University researchers have demonstrated a proof of concept for the mass-production of genome-edited T cells that can be used to treat malignant tumors, using a genetic engineering technique called Platinum TALEN.
A team of researchers reports the creation of an AI test that predicts the risk of breast cancer recurrence—one that does so more quickly and more inexpensively than current methods, which involve genomic testing.
To help healthcare facilities, clinicians, and public health agencies prepare for future Andes virus outbreaks, researchers from Mass General Brigham systematically surveyed the published literature for prior reports of Andes virus exposure in healthcare settings. Based on eight studies from seven Andes virus transmission events, the researchers concluded that incidents of Andes virus transmission to healthcare personnel were associated with delays in implementing transmission-based precautions or control measures. Their findings are published in Clinical Infectious Diseases.