A team from the Monash University Biomedicine Discovery Institute in Australia has identified a tick-derived evasin that can bind to two major classes of chemokines, a discovery that is important for the development of therapeutics targeting inflammatory and autoimmune diseases. Until now, scientists had identified only evasins that selectively block chemokines within a single class.

Reduced international donor funding associated with higher household economic burden of Tuberculosis in low- and middle-income countries, according to modelling stud

Study reveals how two proteins cooperate in a key early step of antiviral detection, as reported by researchers at Science Tokyo. Using cryo-electron microscopy and high-speed atomic force microscopy, they found that LGP2 binds to viral RNA and recruits MDA5 molecules, as if threading beads on a string. This creates a scaffold that facilitates the formation of a large signaling complex, which ultimately triggers an innate immune response.