Cancer metastasis, the spread of cancer to organs, is a major cause of cancer-related deaths. Once cancer spreads to multiple organs, conventional treatments like surgery, radiation, and chemotherapy become less effective. Scientists at Shinshu University School of Medicine have developed a synthetic mRNA that, when injected, revitalizes the immune system to recognize and attack metastasizing cancer cells. This breakthrough could lead to new therapies to improve survival rates for cancer patients.

A groundbreaking study introduces a novel Transformer-based time-series framework designed to predict daily risk alerts for sepsis patients in the Intensive Care Unit (ICU). This model, leveraging sequential data from the eICU database, dynamically captures evolving health trajectories, enabling real-time identification of high-risk patients and actionable insights for personalized interventions. The study, titled “Predictive model for daily risk alerts in sepsis patients in the ICU: visualization and clinical analysis of risk indicators” published in Precision Clinical Medicine February 8, 2025, demonstrates exceptional predictive power, with an AUC increasing from 0.87 on admission day to 0.92 by day 5, offering a new paradigm for ICU prognostics.

A new study reveals that Epstein-Barr virus (EBV) infection exacerbates ulcerative colitis (UC) by driving macrophage pyroptosis through the upregulation of glycolysis. This finding provides a potential therapeutic target for mitigating EBV-induced intestinal inflammation. The study, titled "Epstein-Barr virus infection exacerbates ulcerative colitis by driving macrophage pyroptosis via the upregulation of glycolysis," was published on January 21, 2025, in Precision Clinical Medicine.