Smart mRNA drugs that listen to the body: A new era in precision medicine
Peer-Reviewed Publication
Updates every hour. Last Updated: 13-Oct-2025 08:11 ET (13-Oct-2025 12:11 GMT/UTC)
A research team from The University of Osaka and Institute of Science Tokyo has developed a groundbreaking class of mRNA medicines that can sense changes in the body and autonomously adjust their therapeutic effect. This innovation paves the way for precision treatments that are not only more effective, but also safer—by producing just the right amount of medicine based on real-time biological signals.
Researchers have found that the anti-aging drug Rapamycin extends lifespan as effectively as eating less.
Dietary restriction has long been considered one of the most reliable methods for increasing lifespan across species. But if fasting for hours sounds unpleasant, science may suggest another route to achieving a longer and healthier life.
A new study reveals that Rapamycin, a compound originally developed as an immunosuppressant, offers comparable life-extending benefits in eight species of vertebrates (not including humans).
In this, the largest study of its kind, the team investigated the effect of Rapamycin and Metformin on longevity - both of which have been touted as life-extending drugs.
They found that Rapamycin extends lifespan almost as consistently as eating less, while the Type 2 diabetes medicine, Metformin, does not.
Intermittent fasting diets appear to have similar benefits to traditional calorie-restricted diets for weight loss, suggests an analysis of trial evidence published by The BMJ today.