An MIT study reveals how rare variants of a gene called ABCA7 may contribute to the development of Alzheimer’s by disrupting lipid metabolism in neurons.

About The Study: This trial found that a 12-week high-intensity interval training intervention did not improve hippocampal integrity or associated cognitive or mental health impairments while people continued to consume cannabis. However, results indicated that people with cannabis use disorder can engage in regular physical exercise programs and highlighted exercise as a potential strategy to reduce cannabis craving. 

Lung tumors don’t just evade the immune system. They reshape it at its source. Researchers from the Icahn School of Medicine at Mount Sinai and collaborators report in the September 10 online issue of Nature [10.1038/s41586-025-09493-y] that tumors rewire immune cells in the bone marrow before they even reach the cancer, suggesting a new target to enhance the durability of current immunotherapy. Immunotherapies, which rally the body’s defenses against cancer, have transformed care for many patients. But in solid tumors like non-small cell lung cancer (NSCLC), their success is often blunted by an influx of pro-tumoral macrophages—immune cells that suppress the body’s anti-cancer response. Until now, scientists thought these macrophages turned rogue only after reaching the tumor.

Small cell lung cancer often metastasizes to the brain. A Stanford Medicine-led study shows the cancer cells form synapses with neurons, and signaling across these synapses encourages tumor growth.

Two-thirds of clinical trial participants treated with psilocybin-assisted therapy for major depressive disorder were in complete remission from their depression five years later, a new study has found. 

Stable weight was associated with better cognitive health, while weight variability and weight loss were related to faster cognitive decline, according to a new study by researchers in the Penn State Department of Nutritional Sciences.