MIT study explains how a rare gene variant contributes to Alzheimer’s disease
Peer-Reviewed Publication
Updates every hour. Last Updated: 31-Dec-2025 02:11 ET (31-Dec-2025 07:11 GMT/UTC)
An MIT study reveals how rare variants of a gene called ABCA7 may contribute to the development of Alzheimer’s by disrupting lipid metabolism in neurons.
Lung tumors don’t just evade the immune system. They reshape it at its source. Researchers from the Icahn School of Medicine at Mount Sinai and collaborators report in the September 10 online issue of Nature [10.1038/s41586-025-09493-y] that tumors rewire immune cells in the bone marrow before they even reach the cancer, suggesting a new target to enhance the durability of current immunotherapy. Immunotherapies, which rally the body’s defenses against cancer, have transformed care for many patients. But in solid tumors like non-small cell lung cancer (NSCLC), their success is often blunted by an influx of pro-tumoral macrophages—immune cells that suppress the body’s anti-cancer response. Until now, scientists thought these macrophages turned rogue only after reaching the tumor.
Two-thirds of clinical trial participants treated with psilocybin-assisted therapy for major depressive disorder were in complete remission from their depression five years later, a new study has found.