Acute sepsis profoundly changes how intravenous fluids behave within the body. Using a sheep model, researchers investigated fluid distribution during health and sepsis following crystalloid infusion. They found that sepsis reduced urine output, impaired vascular responsiveness, and diverted most infused fluid into a nonfunctional interstitial third space. These alterations explain why standard fluid therapy becomes less effective during sepsis and underscore challenges in managing circulation and organ perfusion clinically safely.

Structural alignment in fibrous tissues like myocardium and tendons is a key biomarker of physiological integrity and pathological remodeling. However, conventional imaging relies on staining. Researchers in Korea developed mid-infrared dichroism-sensitive photoacoustic microscopy, a label-free imaging modality that integrates molecular specificity with polarization sensitivity. It quantitatively maps protein content and extracellular matrix alignment in engineered heart tissues, enabling objective assessment of structural integrity and fibrosis without staining. This technique advances histopathology and regenerative medicine.

Researchers have discovered 195 genomic regions jointly associated with schizophrenia and osteoporosis-related traits, mapping to 1376 protein-coding genes involved in metabolism and anatomical development.

Dr. Noritaka Ichinohe discusses three decades of translational neuroscience in a new Genomic Press Interview. His work links primate models to human autism subtypes. The findings reshape global approaches to precision psychiatry.

A rare genetic variant found in families affected by schizophrenia completely abolishes the function of TAAR1, an emerging drug target for psychiatric disorders. The C182F mutation causes a 40% reduction in receptor surface expression and total loss of response to therapeutic compounds in laboratory studies.