Researchers have engineered a way to create miniature, self-assembling blood vessel networks entirely from stem cells in the lab. These vascular organoids form functional vasculature when implanted in vivo and show therapeutic potential for restoring blood flow in ischemic tissues. We believe this work opens new opportunities for treating vascular diseases and advancing vascular biology research.

About The Study: The results of this cohort study suggest that medical cannabis laws and recreational cannabis laws enactment was associated with greater opioid use disorder (OUD) prevalence in Veterans Health Administration patients over time, with the greatest increases among middle-aged and older patients and those with chronic pain. The findings did not support state cannabis legalization as a means of reducing the burden of OUD during the ongoing opioid epidemic.

About The Study: In this cohort study, daily walking volume and walking intensity were inversely associated with the risk of chronic low back pain. The findings suggest that walking volume may have a more pronounced benefit than walking intensity. 

 This comprehensive study provides crucial insights into the changing landscape of respiratory pathogen infections in Guangzhou over an 11-year period. The predominance of MP, particularly among school-age children and females, highlights the need for targeted interventions. The unexpected coagulation profiles in confirmed infections suggest complex pathophysiological mechanisms that warrant further investigation. These findings have important implications for clinical management, diagnostic approaches, and public health strategies in urban settings.

Marcela Maus, MD, PhD, director of the Cellular Immunotherapy Program and the Paula J. O'Keeffe Endowed Chair of the Mass General Cancer Center, is senior author and Stefanie Bailey, PhD, Hana Takei, and Giulia Escobar, PhD of the Krantz Family Center for Cancer Research at Massachusetts General Hospital are co-lead authors of a paper published in Science Translational Medicine, “IFN-g-resistant CD28 CAR-T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor models.”