Researchers successfully deliver mRNA-based drugs to the intestine – without passing through the liver
Peer-Reviewed Publication
Updates every hour. Last Updated: 24-Jul-2025 13:11 ET (24-Jul-2025 17:11 GMT/UTC)
Researchers at Tel Aviv University have achieved a major breakthrough in drug delivery: they have successfully transported lipid nanoparticles encapsulating messenger RNA (mRNA) to the immune system of the small and large intestines — bypassing the liver upon systemic administration. By simply altering the composition of the nanoparticles, the researchers demonstrated that mRNA-based drugs can be directed straight to target cells, avoiding the liver.
In a study on public psychology with regard to the COVID-19 pandemic, researchers from Osaka University found no significant differences among regions of Japan regarding either risk perception or infection-prevention behaviors during the “state of emergency,” suggesting spillover effects between targeted and non-targeted regions. However, risk perception diminished after restrictions were lifted, and both risk perception and hygienic behaviors saw further reductions after the downgrading of the legal status of COVID-19 to that of a common seasonal flu.
Calorie labels on restaurant menus are negatively impacting people with eating disorders, according to a new study published today in the BMJ Public Health.
The review, which is the first of its kind, is led by researchers at King’s College London. It found that individuals who have been diagnosed with an eating disorder changed their behaviours if presented with a menu featuring calorie labels.