Recently, a paradigm-shifting review published in MedComm-Future Medicine redefines the skin as a “central command center” that orchestrates health across multiple organs. Led by Prof. Ting Li’s team at Macau University of Science and Technology, the study identifies key molecular messengers, particularly the immune protein IL-17A, that derive bidirectional signaling along the newly defined “skin-organ axis”. By combining evidence from clinical trials with advanced microfluidic organ-chip models, this work proposes a roadmap for revolutionary therapies targeting systemic diseases from arthritis to depression.

Statisticians from the National University of Singapore (NUS) have developed a pioneering approach for analysing population-scale metabolomic data, marking a major advancement in the precision and depth of metabolic profiling. This new method promises to improve both personalised healthcare and preventive medicine by improving the accuracy and interpretability of metabolic analyses.

The mechanisms underlying embryo implantation failure following in vitro fertilization (IVF), as well as low birth weight and offspring long-term health issues, have long been important unresolved questions. Now, writing in the journal Science Bulletin, a team of researchers from Tongji University, revealing that precisely regulating Wnt signaling during the peri-implantation period can enhances embryo implantation and improves post-implantation intrauterine development and postnatal phenotypes of IVF embryos. The findings provide a vital therapeutic target for enhancing IVF success rates, optimizing pregnancy outcomes, and addressing population growth challenges in clinical settings.

A research team led by Dr. Young-Do Nam at KFRI, in collaboration with Professor Kwang-Soon Kim at POSTECH and KFRI’s partner company EnteroBiome Co., Ltd., conducted a large-scale analysis of gut microbiome data from Korean individuals. They discovered that A. muciniphila is not a single species but consists of four distinct subtypes (A. muciniphila clades I–IV) and that only one subtype is typically present in each individual.